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《Oncology Progress》 2006-06
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The treatment for non-small cell lung cancer:Look back in 40 years and recent advance

Li Jinhan Oncology Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China  
The treatment of non-small cell lung cancer (NSCLC) was not initial 40 years ago.The concept for multimodulaty combination treatment was still constructed.Periphyreal lung cancer operation treatment was lobectomy with lymph nodes sampling.The 5-year survival rate of early stage NSCLC operation treatment was only about 30 percent.Chemotherapy agents in treatment of NSCLC were mainly Nitrogen mustart and Nitromin.1-year survival of advanced NSCLC had only 10 percent.Radiotherapy used deeply x-ray or 60Co.At present,there mainly were several advance:①the progression in operation:systematic lymph nodes resection,reconstruction of airway carina or vascular reconstitution,VATS,and surgery treatment of IV stage NSCLC in some given conditions,such as single lesions of both brain and lung completely resection,respectively,with survival improvement significantly.② the progression in radiotherapy:3DCRT and IMRT could enhance response rate with decreasing radiation damage in the lung.③ the progression in chemotherapy:overall response rate of the 3rd generation chemotherapeutic agents accounting for about 40 percent.The categories including:neoadjuvant chemotherapy,adjuvant chemotherapy,palliative chemotherapy and salvage chemotherapy.Of them,recently,both palliative and adjuvant chemotherapy which may improve survival time have reached consensus.④radiotherapy combination with chemotherapy :radiotherapy plus chemotherapy (concurrent or sequential chemoradiotherapy )being best option for local advanced NSCLC.⑤ the progression in biotherapy:EGFR-TKIs (Iressa or Tarceva ) in treatment of metastatic advanced NSCLC serving as 2nd or 3rd line agents were emphasized in Easthern and westhern countries,respectively.⑥ the progression in bio-chemotherapy:chemotherapeutic agents combination with Avastin treating non-squamous NSCLS ⑦ the progression in traditional Chinese medicine:clearly,traditional Chinese medicine improving quality-life and prolonging survival.
【CateGory Index】: R734.2
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