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《Oncology Progress》 2007-06
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Dermatological toxicities to EGFR inhibitors:Diagnosis and management

Chen Zhendong Bu Lijia Wu Xuwei Du Yingying Department of Oncology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China  
Unlike standard chemotherapy,treatment with the molecular targeted anti-tumor agents is associated with an increased incidence of dermatological toxicities.The resulted significant physical and psycho-social discomfort may lead to interruption or dose modification of the molecular targeted anti-tumor agents.It is urgent and important for further understanding of these toxicities to develop adequate staging systems and mechanistically driven therapies,in which the quality of life and consistent antineoplastic therapy can be ensured.In this article,the authors reviewed the dermatological toxicities of EGFRIs,a typical molecular targeted anti-tumor agents,as well as its incidence,clinical situation, pathogenesis, principle of diagnosis,and management.
【CateGory Index】: R595.3
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