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《Oncology Progress》 2007-06
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Endostar combined with chemotherapy in the treatment of HER-2 negative breast cancer

Yuan Xia~1 Zhang Dongsheng~1 Yuan Zhongyu~1 He Ying~2 Ma Huimin~2 Li Jun~2 Jiang Wenqi~(1#) 1 State Key Laboratory of Oncology in South China,Department of Medical Oncology,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China 2 Huizhou Municipal Center Hospital,Huizhou,Guangdnng,516001,P.R.China  
Objective To explore the effectiveness and safely of endostar-combined therapy in Her-2 nega- tive breast cancer with liver metastisis.Methods Endostar combined with chemotherapy were adminis- trated to 5 advanced breast cancer cases(ER,PR and Her-2 are negative)with liver metastisis,who were confirmed by histopathology or cytopathology.A total of 15mg endostar solved in 500ml of normal sa- line was intravenously admistered from day 1 to day 14,repeated later 7 days.The chemotherapy agents that were not used previously or not cross-resistant were administered simultaneously.The regimen was repeated every 21 days.Results Five patients were totally evaluated for efficacy and side effects after 20 cycles(mean cycle was 4).Among 5 evaluable patients,1 patient achieved CR,2 patients PR,and 1 patient SD and of PD.The objective response rate(RR)was 60%(3/5).The G3/4 toxicities were in- eluded leukopenia(3/5,60%),thrombocytopenia(1/5,20%),nausea/vomiting(5/5,100%), and arrhythmia(1/5,20%),which were mainly related with chemotherapy agents.Conclusion The combination of chemotherapy with endostar provides a well-tolerated and active chemotherapy regimen for advanced breast cancer with liver metastisis.
【CateGory Index】: R737.9
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