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《Oncology Progress》 2009-06
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Expression and signiticance of SVV protein in breast adenosis,adenoma,and carcinoma

Cuan Jian Chen Jie Cao Yufeng Cao Jinling Gao Jie Zhao He Department of Pathology,Peking Union Medical College Hospital,CAMS&PUMC,Beijing 100730,China  
Objective To determine the role of the expression of SVV protein in breast carcinogene- sis,prognosis,and to explore the relationship between SVV and tumor size,apoptosis,and expression of ER,PR,Her-2,P53 proteins.Methods Immunohistochemical staining was performed by twostep EnVision~(TM) technique for the paraffin sections,which included 20 adenosis,20 adenoma,30 ductal carcinoma in situ(DCIS),and 30 invasive ductal carcinoma(IDC) of breast.Results Among these sections,7 of 20 adnosis,6 of 20 denoma,20 of 30 DCIS,and 24 of 30 IDC were SVV-positive.The high expressions were 3/20,1/20,14/30,and 16/30,respectively.There was no difference of SVV expression between adenosis and adenoma of breast(P0.05).SVV expression was not significantly different between DCIS and IDC(P0.05).However,compared to adenosis and adenoma,SVV was significantly expressed in breast carcinoma,both in DCIS and IDC(P0.05).In IDC,SVV expression was not significantly carrelated with tumor size,cell apoptosis,and expression of other proteins such as HER-2, ER,PR,P53,and ki-67.Conclusion SVV expression may help distinguish breast carcinoma from breast adenosis and tubular adenoma.
【CateGory Index】: R737.9
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