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《Oncology Progress》 2013-06
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Effectiveness and safety of single-agent ginsenoside Rg3 maintenance therapy after response to first-line chemotherapy in patients with advanced non-small cell lung cancer

ZENG Dong-xiang;BI Yan-zhi;SHENG Gui-feng;DONG Yi-zhong;SONG Hong-lei;Department of Oncology,Changzhou Tumor Hospital,Soochow University;  
Objective To investigate the clinical efficacy and safety of ginsenoside Rg3 maintenance therapy after the first-line chemotherapy for patients with advanced non-small cell lung cancer(NSCLC).Method A total of 69 patients who responded to the first-line chemotherapy were assigned to single-agent ginsenoside Rg3 maintenance therapy or clinical observation.The maintenance therapy continued until disease progresses or intolerable toxicity occurs.Result 2 patients in treatment group withdrew or lost follow-up,the ratio of progression in maintenance therapy group and observation group were 53.1%vs 62.9%and the median progression-free survival time were,6.5 months us 6.2 months,respectively,both of the two indexes were not significantly different(P 0.05),though there was significant difference in the elevation of T lymphocyte subset and life quality(P 0.05),and there were also more patients in maintenance group received second-line therapy after tumor progressed(P 0.05).Conclusion Maintenance therapy of ginsenoside Rg3 is an effective treatment option for patients with advanced NSCLC who have not progressed after first-line therapy,and is well tolerated.
【CateGory Index】: R734.2
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