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《Oncology Progress》 2019-02
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The clinical efficacy of the combination of chemotherapy and Jiawei Liangfu pill as the treatment for advanced gastric cancer and its effect on the serological markers and quality of life

ZHAO Hang;DAI Wei;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School;  
Objective To analyze the clinical effect of chemotherapy combined with Jiawei Liangfu pills in the treatment for patients with advanced gastric cancer, and investigate the effect on serological markers and quality of life. Method A retrospective analysis including the clinical data of 58 patients with advanced gastric cancer was performed, the subjects were assigned into control group(n=29) or study group(n=29) according to respective therapy administered. The patients in control group were treated with chemotherapy alone, while the study group was treated with combined therapy of chemotherapy and Jiawei Liangfu pills, and then the clinical effect, serological markers and quality of life of the two groups were compared. Result The overall response rate of study group was 48.28% and that of control group was31.03%, with no significant difference observed(P0.05). Before treatment, there was no significant difference regarding the level of tumor necrosis factor-α(TNF-α), interferon-γ(IFN-γ), interleukin-12(IL-12), vascular endothelial growth factor(VEGF), matrix metalloproteinase 2(MMP2), matrix metalloproteinase 3(MMP3), cyclooxygenase-2(COX-2) between the two groups(P0.05). After treatment, the TNF-α, IFN-γ and IL-12 level were significantly higher in study group than those in control group(P0.05), while the level of VEGF, MMP2, MMP3, and COX-2 were lower than those in control group(P0.05). Before treatment, the scores of physical function, role function, emotional function, cognitive function and social function in both groups were similar(P0.05); but all were significantly higher in study group compared with those in control group after treatment(P0.01). Conclusion The combined therapy of chemotherapy and Jiawei Liangfu pills is fairly effective in the treatment for advanced gastric cancer, by improving the level of TNF-α, IFN-γ,and IL-12, while reducing the level of VEGF, MMP2, MMP3, and COX-2, and therefore may ameliorate the quality of life for these patients.
【CateGory Index】: R735.2
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhang Zisen;Ba Nan;Zhang Jian;Wang Yanan;Peng Fanghui;Xue Changnian;Xia Xingzhou;Department of Oncology,the Fifth Affiliated Hospital of Zhengzhou Univesity;Department of General Surgery,the Fifth Affiliated Hospital of Zhengzhou Univesity;Department of Gastroenterology,the Fifth Affiliated Hospital of Zhengzhou Univesity;;Relationship between serum soluble E-cadherin expression and prognosis in gastric cancer patients treated by FOLFOX4 regimen[J];中华实验外科杂志;2016-12
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Liu Lei;Han Liang;Department of Gastrointestinal Surgery,Wuhan Central Hospital,Tongji Medical College,Huazhong University of Science and Technology;;Involvement of phosphatase of regenerating liver-3 and E-cadherin in the process of the lymph node metastasis of gastric cancer[J];中华实验外科杂志;2015-02
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