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《Journal of Bengbu Medical College》 1982-01
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Yu Chuanbin Department of Pharmacology, Bengbu Medical College Bengbu, Anhui  
The anti-inflammatory, antipyretic, analgesic, local anesthetic and toxic effects of Pelagonium gcravcolens were studied in this article. The LD 50 of the drug in mice given p.o. was found to be 3.66±0.24g/kg. Its toxicity is very low. It inhibited significantly the increase of capillary permeability induced by acetic acid. It also inhibited the exudation, and the inflammation on the ear induced by croton oil, but it was of no effect on granule ma. formation. This drug given p.o. elevated the cortisol level of plasma in mice and also promoted the phagocytosis of macrophages in mice. The anti-inflammatory activity may be related to the promotion of the secretion of corticosteroids and the enhancement of the immune response. For the explanation of this phenomenon further works have to be done. Its analgesic action by the hot plate and stretching method was weaker but longer than that of Dolantin. It possesses a moderate local anesthetic activity.
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