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《JOURNAL OF BENGBU MEDICINAE COLLEGE》 2000-05
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Antagonistic effect of gypenoside on diaphragm against doxorubicin cytotoxicity

MA Shan feng,LU Zong lan,GUAN Su dong,LIU Gui lan (Department of Physiology,Bengbu Medical College,Anhui 233003 ,China) [  
Objective:To study the antagonistic effect of gypenoside(GP) on diaphragm against adriamycin cytotoxicity in rabbits.Methods:The toxicant effect on diaphragm of doxorubicin and the antagonistic effect of GP were examined by measurements of diaphragm evoked potential(DEP) and the transdiaphragmatical pressure(Pdi) and observation of the ultrastructure of diaphragm.All data were evaluated by q test.Results:(1)The amplitude of DEP and the Pdi were markly decreased in rabbits treated with doxorubicin( P 0.01 and P 0.05) ;(2)The disorder of myofibrills and swelling of mitochondria with broken cristae were observed in doxorubicin group;(3)The above mentioned changes were inhibited by gypenoside.Conclusions:The results showed that the gypenoside could antagonize the toxic effect of doxorubicin and protect the diaphragm myocytes. [
【CateGory Index】: R96
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