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《Journal of Bengbu Medical College》 2004-03
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Influence of soybean isoflavones on adriamycin-induced heart failure in rats

WU Bei jing,SUN Yu,XU Qing li,WU Xiang,ZHANG Kang jian,GUO Ling (Faculty of Clinical Medicine,Bengbu Medical College,Anhui 233003,China)  
Objective:To observe the protective effect of soybean isoflavones(SI) on adriamycin(ADR) induced heart failue in rats.Methods:Twenty four adult male SD rats were divided into 3 groups:normal contrasted(NC)group,ADR group and SI group.SI 120 mg·kg -1 ·d -1 was administered using a stomach tube in SI group once a day for 6 days.The other two groups were given the same amount of normal saline(NS).At day 7,ADR 10 mg/kg was given intraperitoneally(ip) at one time to copy the model of heart failure rats.The LVSP of the rats was recorded,observed and analyzed using the MedLab U/4c biological signal collecting system.Results:Compared with NC group,the LVSP,±dp/dt max and Vpm of ADR group decreased significantly ( P 0.05 to P 0.01 );but the LVSP,±dp/dt max and Vpm of SI group increased significantly( P 0.05 to P 0.01) compared with those of ADR group.Conclusions:SI can relieve the toxic effect of ADR on myocardiam and greatly improve the contractivity of heart failure in rats.
【CateGory Index】: R541.6
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