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《Journal of Bengbu Medical College》 2005-03
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Expression of survivin mRNA in lung cancer tissue and its relationship with prognosis

LI Dian-ming~1,LIU Chao~1,CHEN Yu-qing~1,XIA Xue-mei~1,HUANG Li-nian~1,LI Bai-qing~2(1.Department of Respiratory Diseases,Affiliated Hospital of Bengbu Medical College,Bengbu 233004;2.Department of Immunology,Bengbu Medical College,Bengbu 233003,China)  
Objective:To assess the value of detection of survivin mRNA in lung cancer tissues.Methods:The specimens and the para-carcinomatous normal tissues of 41 patients with lung cancer and 9 patients with benign pulmonary diseases were collected.Reverse transcriptase polymerase chain reaction(RT-PCR) was performed to detect the survivin mRNA expression in the specimens.All the patients were followed-up for 2 years.The results were analyzed relatively.Results:The positive rate of survivin mRNA in the carcinomatous tissues(70.7%) was higher than that in the para-carcinomatous normal tissues(17.1%) and the benign pulmonary diseases tissues(1/9)(P0.005).There was no significant difference between the para-carcinomatous normal tissues and the benign pulmonary diseases tissues(P 0.05).survivin mRNA expression was not related to the age,sex,histological subtype,differentiation,pathologic grading or lymph node metastases.Conclusions:Expression of survivin mRNA in the lung cancer tissue can be used as a specific molecular marker for the diagnosis of lung cancer.It can act as an independent prognostic factor.
【Fund】: 安徽省自然科学基金资助项目 (0 3 0 43 70 5 )
【CateGory Index】: R734.2
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【References】
Chinese Journal Full-text Database 2 Hits
1 HUO Xiao-dong,SUN Qin-nuan,LI Guo-hua (Department of Nephrology,central Hospital of Baotou,Baotou 014040 China);EXPRESSION AND CLINICAL SIGNIFICANCE OF SURVIVIN,CASPASE-3,GST AND PGP IN NSCLC[J];Acta Academiae Medicinae Neimongol;2006-04
2 GUO Wen-feng.Center Hospital of Baotou City,Inner Mongolia 014010,China;Expression and clinical significance of Caspase-3 GST Pgp in non-small-cell lung cancer[J];Journal of Clinical Pulmonary Medicine;2010-04
【Citations】
Chinese Journal Full-text Database 4 Hits
1 XIA Xue-mei 1,CHEN Yu-qing 1,CAI Ying-yun 2,LI Dian-ming 1,HU Jun-feng 1,HUANG Li-nian 1 (1.Department of Respiratory Diseases,Affiliated Hospital of Bengbu Medical College,Anhui,233004;2.Pulmonary Department,Sun Yat-sen Hospital Affiliated to Fudan University,Shanghai 200032,China);The synergic effect of survivin antisense oligonucleotide on apoptosis in lung cancer cell lines[J];Journal of Bengbu Medical College;2005-01
2 WANG Xiaoyang,CHEN Shixin,ZHANG Zhenxiang,et al Research Laboratory of Respiratory Disease ,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Expression of survivin gene and its relationship with expression of P53,c-myc,k-ras proteins in non-small-cell lung cancer[J];Chinese Journal of Tuberculosis and Respiratory Diseases;2001-06
3 ZHU Hongxia, LIU Shuang, ZHOU Cuiqi, ZHOU Xiaobo, ZHANG Fan, JIN Lanping, XU Ningzhi. Laboratory of Cell and Molecular Biology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Anti-apoptosis gene survivin promotes cell growth and transformation[J];National Medical Journal of China;2002-05
4 WANG Xingyuan, SUN Yan, LI Weidong et al. Department of Medical Oncology, National Laboratory of Molecular Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021;Alterations of FHIT gene and p16 gene in lung cancer and metastatic hilar lymph nodes[J];CHINESE JOURNAL OF ONCOLOGY;1999-02
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 LI Guoren, DAI Jianhua, WANG Yanqing, CHEN Guanghui, LIU Xiaofeng, MIAO Fulu, Bai Ling, CHEN Yulin. Department of Chest Surgery, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu 222002, P.R.China;Overexpression and its clinical significance of multi-drug resistance associated genes in lung cancer tissues[J];Chinese Journal of Lung Cancer;2002-01
2 Li Xi;Guo Xianjian;Li Shuping(Affiliated Xinqiao Hospital,Third Military Medical University,Chongqing,630037);Expression of P-Glycoprotein in Non-Samll-Cell Lung Cancers[J];THE PRACTICAL JOURNAL OF CANCER;1996-01
3 ZHAO Qi-feng, WANG Sheng-li, HU Xing-ti, ZHAO Zi-niu, DU Jie, ZHANG Yue-feng. (Department of Thoracic and Cardiovascular Surgery, the 2nd Affiliated Hospital, Wenzhou Medical College, Wenzhou 325027, Zhejiang, P.R.China);Expression and clinical significance of LRP、P-gp、GST-π、TopoⅡ in lung cancer[J];Chinese Journal of Clinical Thoracic and Cardiovascular Surgery;2003-03
4 Yi Cheng, Hu Yichuan, Hou Mei, et al. Cancer Center, The First University Hospital, West China University of Medical Science, Chengdu, Sichuan 610041, P.R. Chian.;Study on Expression of MDR 1 Gene Product in Non small Cell Lung Cancer[J];CHINESE JOURNAL OF CLINICAL THORACIC AND CARDIOVASCULAR SURGERY;1997-02
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 WANG Li-hong,LI Guo-hua,SUN Qin-nuan,et al.(Department of Respiration Medicine,Affiliated Hospital,Inner Mongolian Medical College,Hohhot 010050 China);EXPRESSION AND ITS CLINICAL SIGNIFICANCE OF GST-Π,TOPO-Ⅱ IN NON SMALL-CELL LUNG CANCER BEFORE CHEMOTHERAPY[J];Acta Academiae Medicinae Neimongol;2007-03
2 CHENG Ling,WU Yan(Department of Pathology,Inner Mongolia Medical College,Hohhot 010059 China);PROGRESS OF RESEACH IN SURVIVIN,Fhit GENE AND GLOMA[J];Acta Academiae Medicinae Neimongol;2007-S1
3 ZHAO Xiang-dong,DOU Chang-wu,WANG Xiao-juan,et al.(Department of Neurosurgery,Affiliated Hospital,Inner Mongolia Medical College,Hohhot 010050 China);PROGRESS OF SURVIVIN AND GLIOMA[J];Acta Academiae Medicinae Neimongol;2008-S1
4 GU Yan,SUN Qin-nuan,FU Xiu-hua,et al.(Department of Respiratory Medicine,Affiliated Hospital,Inner Mongolia Medical College,Hohhot 010050 China);EXPRESSION AND SIGNIFICANCE OF MUTANT p53,MDM2 AND CASPASE-3 IN NON-SMALL CELL LUNG CANCER[J];Acta Academiae Medicinae Neimongol;2009-01
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Zhi 2) , MEI Zhu zhong 1) , TONG Xin 1) , DONG Yan 1) , LI Qing shan 2) , SUN Zhi xian 1)* ( 1) Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China ; 2) Academy;Antisense Oligonucleotide Targeting Survivin Inhibits the Proliferation of Cancer Cells[J];Chinese Journal of Biochemistry and Molecular Biology;2001-06
2 WANG Mei,WANG Bing,WANG Xiao li, et al 1st Hospital of Xi′an Communication University(Xi′an,710061);PRELIMINARY STUDY ON THE EXPRESSION OF SURVIVIN PROTEIN IN CERVICAL INTRAEPITHELIAL NEOPLASIA AND CERVICAL CARCINOMA[J];Cancer Research and Clinic;2001-04
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