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《Journal of Bengbu Medical College》 2005-03
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Expression of survivin mRNA in lung cancer tissue and its relationship with prognosis

LI Dian-ming~1,LIU Chao~1,CHEN Yu-qing~1,XIA Xue-mei~1,HUANG Li-nian~1,LI Bai-qing~2(1.Department of Respiratory Diseases,Affiliated Hospital of Bengbu Medical College,Bengbu 233004;2.Department of Immunology,Bengbu Medical College,Bengbu 233003,China)  
Objective:To assess the value of detection of survivin mRNA in lung cancer tissues.Methods:The specimens and the para-carcinomatous normal tissues of 41 patients with lung cancer and 9 patients with benign pulmonary diseases were collected.Reverse transcriptase polymerase chain reaction(RT-PCR) was performed to detect the survivin mRNA expression in the specimens.All the patients were followed-up for 2 years.The results were analyzed relatively.Results:The positive rate of survivin mRNA in the carcinomatous tissues(70.7%) was higher than that in the para-carcinomatous normal tissues(17.1%) and the benign pulmonary diseases tissues(1/9)(P0.005).There was no significant difference between the para-carcinomatous normal tissues and the benign pulmonary diseases tissues(P 0.05).survivin mRNA expression was not related to the age,sex,histological subtype,differentiation,pathologic grading or lymph node metastases.Conclusions:Expression of survivin mRNA in the lung cancer tissue can be used as a specific molecular marker for the diagnosis of lung cancer.It can act as an independent prognostic factor.
【Fund】: 安徽省自然科学基金资助项目 (0 3 0 43 70 5 )
【CateGory Index】: R734.2
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