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《Journal of Bengbu Medical College》 2005-04
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Expression of Caspase-3 in bladder transitional carcinoma and its significance

YNAG Xiao-huai1,LI Qing-wen1,ZHANG Jia-jun1,CHENG Ze-nong2(1.Department of Urology,Affiliated Hospital of Medical College,Bengbu 233004;2.Department of Pathology,Bengbu Medical College,Bengbu 233003,China)  
Objective:To investigate the expression of Caspase-3 to evaluate the effect on the tumorigenesis and progression in normal bladder mucous membrane and bladder transitional carcinoma(BTCC).Methods:The immunohistochemistry (S-P method) was used to determine the expression of Caspase-3 in 46 case of BTCC and 10 normal bladder mucous membranes.Results:The protein expression level of Caspase-3 in BTCC(47.83%) was significantly lower than that in normal bladder samples(90.00%)(P0.01).Caspase-3 expression level was correlated with the grading of BTCC(P0.01),but had no significant correlation with clinical staging(P0.01).Conclusions:Decrease of expression of Caspase-3 may play an important role in the tumorigenesis of bladder carcinoma.
【Fund】: 安徽省高等学校青年教师科学研究资助项目(2004jq176)
【CateGory Index】: R737.14
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