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《Journal of Bengbu Medical College》 2006-04
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The effects of sodium butyrate on proliferation and apoptosis of esophageal carcinoma Eca-109 cells

SHEN Rong,TAO Yi-sheng (Department of Pathology,Bengbu Medical College,Bengbu 233030,China)  
Objective:To investigate the effects of sodium butyrate(NaB) on proliferation and apoptosis of esophageal carcinoma Eca-109 cells.Methods:Eca-109 cells was treated with NaB in concentration of 1,2.5,5 mmol/L.Morphological changes of Eca-109 cells were observed by inverted microscope.The morphology of apoptotic cells was investigated by transmission electronic microscope.The inhibition rate of cell growth was assessed by MTT assay.TUNEL assay was used for estimating apoptotic rate.Results:Treatment of Eca-109 cells with NaB resulted in significant inhibition of cell growth in time-dependent and dose-dependent manners.Cells became small and round,many of them fell off from the wall under light microscopy.NaB could reduce the solidity of nuclei,make the chromatin condense and get together into karyotheca.NaB inhibited the growth rate of cells obvioursly,the growth rates of cells treated with NaB in concertrations of 1,2.5,5 mmol/L for 24 h,48 h and 72 h were 13.38%,34.15%,39.02%;14.04%,33.33%,46.49%;and 31.11% ,40.74%,48.15%,respectively(P0.05-P0.01).The rates of cell apoptosis in the group treated with 2.5 mmol/L NaB for 24 h and control group were 5.5% and 1.6%,respectively(P0.05).Conclusions:Sodium butyrate could inhibit the proliferation and promote the apoptosis in esophageal carcinoma Eca-109 cells in time-dependent and dose-dependent.
【Fund】: 安徽省教育厅自然科学研究资助项目(2002kj209)
【CateGory Index】: R735.1
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