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《Journal of Bengbu Medical College》 2006-04
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Protective effects of gypenosides on the heart injury after intestinal ischemia-reperfusion in rabbits

GE Jun,ZHU Yu-jie,WU Jun,YAO Bei-bei (Faculty of Clinical Medicine,Bengbu Medical College,Bengbu 233030,China)  
Objective:To observe the injurious effect on heart induced by ischemia-reperfusion and the protective effect of Gypenosides (Gyp) in rabbits.Methods:Twelve adult rabbits were divided into two groups:mormal control(NC)group and Gyp group.10 mg/L Gyp was administered iv. in Gyp group once a day for three days,the NC group was given the same volume normal saline the same way.The fourth day,intestinal ischemia-reperfusion was produced by occluding the mesenteric artery in rabbit.Venntricular pressure was collected and analyzed by the Medlab-U/4c .Results:LVSP,±dp/dt_ max ,Vpm between NC group and Gyp group were not significantly different (P0.05) before mesenteric artery were occluded. But compared with NC group,LVSP,+dp/dt_ max ,Vpm in Gyp group were markedly increased(P0.01) and-dp/dt_ max was obviously decreased(P0.01) after ischemia-reperfusion.Conclusions:Intestinal ischemia-reperfusion can cause the heart injury,and Gyp can improve the contractions of heart and relieve the injury.
【CateGory Index】: R285.5
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