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《Journal of Bengbu Medical College》 2007-04
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Protective effect of gypenosides on adriamycin induced acute cardiotoxicity in rats

ZHANG Jin,WANG Chang-jun,XIE Jiang,CHEN Fang(Faculty of Pharmacology,Bengbu Medical College,Bengbu 233030,China)  
Objective:To observe the protective effect of gypenosides(Gps)on adriamycin(ADR)induced acute cardiotoxicity in rats.Methods:Rats in Gps group received gypenosides 200 mg/kg orally twice a day for five days.In the meanwhile,the saline was given to ADR group and normal rats as controls.At the sixth day,the acute heart toxicity was induced by intraperifoneal injecting ADR(10 mg/kg).Subsequently,the functions of cardiac muscle,such as left ventricular systolic pressure(LVSP)and left verfricle maximal rates of pressure development and decline(+dp/dtmax),as well as the activity of SOD and content of MDA were measured.Results:LVSP,+dp/dtmax and the activity of SOD in rats of ADR group were significantly lower,and the content of MDA was higher than those in controls(P0.01).LVSP,+dp/dtmaxand the activity of SOD in rats of Gps group were significantly higher and the content of MDA was significantly lower than those without giving gypenosides(P0.05-P0.01).Conclusions:Gyp secure cardiac muscles and their function from adriamycin impairment.
【CateGory Index】: R285
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