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《Journal of Bengbu Medical College》 2008-04
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Effect of Tiaoqi Huoxue Bushen decoction on experimental renal injury in rats

MA Wen-bo1,GAO Xin-chun2,WANG Jian-yi1,YANG Shu-wen3 (1.Department of Urology Surgery,The Frist Hospital of Zhangjiakou,Zhangjiakou Hebei 075000;2.First Affiliated Hospital,Hebei North University,Zhangjiakou Hebei 075000;3.Second Affiliated Hospital,Hebei Medical University,Shijiazhuang Hebei 050061,China)  
Objective:To observe the effect of Tiaoqi Huoxue Bushen decoction on the nitric oxide(NO) and lipid overoxidation of renal homogenate in rats with chronic renal failure(CRF).Methods:The Wistar rats were resected five sixths of the kidney under anesthetization by ether to make animal models of chronic renal failure.After 5 weeks,the CRF rats were administered 13.9 g/kg BW and 27.8 g/kg BW for 10 weeks.All the rats were killed after 4 and 10 weeks,and the reanl homogenate was made.The relevant indexes such as NO,nitric oxide synthase(NOS),superoxide dismutase(SOD) and malondialdehyde(MDA) were measured in the reanl homogenate.Results:The model of CRF rats was successfully established.The activity of NO and NOS in the reanl homogenate of CRF rats rose obviously at the early stage and descented at the later period.The over-rise and persistent decrease of the activity of NO and NOS were obviously inhibited after the administration of Tiaoqi Huoxue Bushen decoction for 4 weeks and 10 weeks,respectively.With the prolonging of the desease,the SOD activity in the nephridial tissue of the CRF rats kept decreasing,and the content of MDA kept decreasing.After the therapy of Tiaoqi Huoxue Bushen decoction,the SOD activity and the content of MDA in the nephridial tissue of the CRF rats improved significantly.The effect was more obvous in the group treated with a large dose than in that receiving a small dose.Conclusions:The results demonstrate that Tiaoqi Huoxue Bushen decoction can improve and adjust the synthesis of NO,and decrease the free radical injury as well.
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 3 Hits
1 Hou Lianbing Deng Hongzhu Chen ZhiliangShi Xinghua Luo Guixiang Liao Xilin(Dept. of Clin. pharmacal of Sonth Hospital, First Military Med. Univ. Guangzhou 510515);PREARATION AND MEANINGFULNESS OF THREE KINDS OF ANIMAI MODELS OF CHRONIC RENAL FAILURE (CRF)[J];West China Journal of Pharmaceutcal Sciences;1994-03
2 XIAO Wei, MA Yun, FU Jiangnan (Department of Chinese Traditional Medicine, the First Military Medicine University, Guangzhou 510515,China);Present Study Condition of the Methodology on CRF Animal Model[J];Chinese Journal of Laboratory Animal Science;2002-03
3 Zhang Xiaoli,Wang Guilan,Dong Jianjun,et al.Department of Endocrinology,First Affiliated Hospital,Shandong Medical University,Jinan,250012;Relationship between circulating nitric oxide level and renal function in diabetic patients[J];CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM;1998-01
Chinese Journal Full-text Database 10 Hits
1 ZHAO Hai-feng1,2,ZHANG Zhao-feng1,LI Qiong1,ZHAO Ming1,LI Yong1(1.Department of Nutrition and Food Hygiene,School of Public Health,Beijing University,Beijing 100083;2.Department of Nutrition and Food Hygiene,School of Public Health,Shanxi Medical University,Taiyuan 030001,China);Adenine-induced Chronic Renal Function Impairment in Rats[J];Carcinogenesis,Teratogenesis & Mutagenesis;2008-05
2 GENG Jing(Department of Chinese Medicine,Renmin Hospital of Huaibei City,AnHui Province,Anhui Huaibei 235000,China);Clinical Observation on Chinese Medicinal Herbal Retention-enema to Treat 66 Cases of Chronic Renal Failure[J];Journal of Anhui Traditional Chinese Medical College;2006-01
3 LIU Xiang-mei,WU Yu-qiang,YAN Qiu,TANG Yao-han,TAN Jun(College of Physical Education Science,Hunan Normal University,Changsha 410012,Hunan China);Changes of Nitric Oxide Content in Rat's Kidney at 24 Hours after Exhaustive Exercise[J];Journal of Beijing Sport University;2008-10
4 ZHANG Yao-quan,FENG Bing,YUAN Fa-huan(Renal Diseases Research Center of PLA,Department of Nephrology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Establishment of the rabbit model of chronic renal failure by the branchs′ deligation of arteria renalis[J];Chongqing Medicine;2008-18
5 LI Dan,ZHAO Xue-zhi~*(Department of Nephrology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China);High phosphorus foods combined with 5/6 nephrectomy for establishing rat hyperparathyroidism model secondary to chronic renal failure[J];Academic Journal of Second Military Medical University;2006-07
6 ZHANG Qiao-ling~(1),DONG Chang-sheng~(1),ZHAO Hui-ming~(2)(1.Shanxi Agricultural University,Taigu,Shanxi,030801,China;2.Changzhi Vocational Technology Institute,Changzhi,Shanxi,046000,China);Regulating Action of NO on Placenta Function and Foetus' Growth[J];Progress In Veterinary Medicine;2005-11
7 YU Jie1,ZHAO Jing-hong2,DENG Meng-yang1,HUANG Lan1(1Institute of Cardiovascular Diseases,2Renal Diseases Research Center,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Establishment and evaluation of uremic atherosclerosis models in ApoE~(-/-) mice[J];Acta Academiae Medicinae Militaris Tertiae;2009-19
8 ;人参养荣汤对慢性肾功能衰竭腹膜透析营养不良大鼠模型的治疗作用[J];Chinese Journal of Integrated Traditional and Western Nephrology;2000-01
9 ZHANG Yaoquan,FENG Bing,Li Furong,et al Renal Diseases Research Center of PLA,Department of Nephrology,Xinqiao Hospital,Third Military Medical University,Chongqing(400037);Observation of Accelerated Atherosclerotic Pathomorphology of the Rabbit Model of Chronic Renal Failure[J];Chinese Journal of Integrated Traditional and Western Nephrology;2008-06
10 ZHOU Xijiang, LIU Kangzong, WU Jun,et al.Department of Endocrinology Wuhan Third Hospital, Wuhan 430060,China;Changing of urine NO releasing in type 2 diabetes patients with hypertention.[J];Journal of Clinical Internal Medicine;2001-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Yuan Fahuan , Liao Lisheng (Department of Nephrology, Xinqiao Hospital, Third Military Medical College, Chongqing, 630037);Establishment and evaluation of the cadmium-induced mouse model of chronic renal failure[J];Acta Academiae Medicinae Militaris Tertiae;1993-06
2 Wang Yaoguang The Second Affiliated Hospital of Tianjing College of TCM(300150);A Primary Approach to the Nature of Blood Stasis of Animal Model with Chronic Renal Failure Caused by Electric Cauterization[J];HENAN TRADITIONAL CHINESE MEDICINE;1997-01
3 Zhou Xiaozhou ;Zhang Shengguang; Yang Xiao; Wei Yi (Hunan College of TCM, Changsha, China410007);Study on Mechanism of Adenine-Induced Chronic Renal Failure in Rat[J];BASIC MEDICAL SCIENCES AND CLINICS;1997-01
4 Lin Na, Chen Ronghua, Huang Songming, et al. Center of Pediatric Nephrology, Nanjing Medical University, Nanjing 210029;Modified Animal Model of Rapid Glomerulosclerosis[J];ACTA ACADEMIAE MEDICINAE NANJING;2000-03
5 Wang Wei,Wang Qingzhou,Chen Xueyan et al(National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050);Establishment of Rat Model of Chronic Renal Failure Caused by Adenine[J];CHINESE JOURNAL OF BIOLOGICALS;1999-02
6 XIONG Zu Ying, MEI Qiao, DING Chang Hai, XU Shu Yun (Dept of Nephrology, The First Hospital of Anhui Medical University Insititute of Clinical Pharmacology, Anhui Medical University, Hefei 230032);A model of adriamycin induced nephropathy after pinealectomy[J];CHINESE PHARMACOLOGICAL BULLETIN;1999-03
7 Deng Hongzhu,Jin Weijun,Hou Lianbing and Liao Xilin(Nanfang Hospital,First Military Medical University,Guangzhou 510515);Methodology of Pharmacodynamic Study on Chronic Renal Failure[J];CHINA JOURNAL OF CHINESE MATERIA MEDICA;1998-04
8 Du Jidfu,Cui Dejian,Tian Donghua,et al.Division of Respiratory Medicine,304 Hospital,P·L·A·,Beijing 100037;The role of nitric oxide in the pathogenesls of asthma[J];CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES;1997-03
9 XIE Pingchu,LU Jiaqi,SUN Daming,et al.Department of General Surgery,304th Hospital of PLA,Beijing 100037;Changes in peripheral and internal microcirculation in pigs with endotoxic shock[J];CHINESE CRITICAL CARE MEDICINE;1999-12
10 JIANG Zhibin,LIU Lijun,WANG Ying,ICU,Second Affiliated Hospital of Suzhou University,Suzhou Jiangsu 215004;Study on the effects of nitric oxide inhalation on the improvement of oxygenation and hemodynamic status in patients with septic shock complicated with acute respiratory distress syndrome[J];CHINESE CRITICAL CARE MEDICINE;2000-09
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