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《Journal of Bengbu Medical College》 2008-04
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Influence of Ginkgo Biloba Extract on neural cell apoptosis and ultrastructure in ischemic penumbra after cerebral ischemia/reperfusion in rats

LI Jian-jun1,ZHANG Xiao-Lei2,WANG Xiao-shan2,SUN Qi2,ZHANG Ling-ru2 (1.Department of Neurology,Tianchang People's Hospital,Tianchang Anhui 239300;2.Department of Neurology,Nanjing Brain Hospital,Nanjing Medical University,Nanjing Jiangsu 210029,China)  
Objective:To investigate the influence of Ginkgo Biloba Extract on neural cell apoptosis and urtra micro-structure of neural cells in cerebral ischemic penumbra after cerebral ischemia/reperfusion in rats.Methods:Thirty male Wister rats were randomly divided into sham-operation group(n=6),control group(n=6) and treatment group(n=6).The treatment group were injected intraperitoneally Ginkgo Biloba Extract 761(20 mg/kg) before and after middle cerebral artery occlusion;the sham-operation group and control group were injected normal saline(20 mg/kg).Animal models were established by middle cerebral artery occlusion.The number of nerual cell apoptosis was measured by thymidine/deoxythymidine mediated dexoy UTP-biotin nick and labeling(TUNEL),and the changes of ultra micro-structure of neural cells were observed by electromicroscope.Results:The number of neural cell apoptosis was 21.2±3.8 in control group after ischemia 90 min/reperfusion 12 h,versus 9.1±2.3 in Ginkgo Biloba Extract-treated group after ischemia 90 min/reperfusion 12 h,the difference was significant(P0.01).The neuron apoptotic cells were observed by their fragmented nuclei condensed chromatin,fragmented or condensed cytoplasm and floccule of mitochondrion in the control group after ischemia 90 min/ reperfusion 12 h;whereas the distribution of chromatin was well-proportioned,and normal mitochondrion and other organelle were observed in the Ginkgo Biloba Extract-treated group.Conclusions:As platelet-activating factor receptor antagonists,Ginkgo Biloba Extract has remarkable neuroprotective effect.
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 1 Hits
1 QU Ying(Department of Neurology,Chongqing Emergency Medical Center,Chongqing 400014,China);Research on treatment effects of Ginkgo Biloba Extract on chronic cerebral circulation insufficiency[J];Chongqing Medicine;2010-18
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1 XU Bin, XU Zhong-bao,GAO Feng-ling,et al. (Department of Neurology,Fuxing Hospital affiliated to Capital University,Beijing 100038, China);Diagnostic value of transcranial Doppler ultrasound for stenosis of extracranial internal carotid artery[J];Journal of Apoplexy and Nervous Diseases;2005-05
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