Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Bengbu Medical College》 2009-01
Add to Favorite Get Latest Update

Effect of Sini decoction on cerebral injury after cardiopulmonary resuscitation in rats

ZHAO Jin1,2,YANG Wei-dong2,WANG Si-ying1(1.Department of Pathophysiology,Anhui Medical University,Hefei Anhui 230032;2.Department of Pathophysiology,Bengbu Medical College,Bengbu Anhui 233030,China)  
Objective:To explore the effect of Sini decoction(SND) on the activity of lactate dehydrogenase(LDH) and the concentration of malondialdehyde(MDA) after cardiopulmonary resuscitation(CPR) in rats.Methods:Adult Wistar rats were randomly divided into 3 groups,the normal control group,the CPR group and the SND treatment group.Model of CPR was produced by injecting 2% KCl quickly through external jugular vein.Then the rats,heartbeat and respiration stoped at once,after 6 minutes were carried out CPR.For being observed for 60 minutes,adult Wistar rats were sacrificed.The activity of LDH and the concentration of MDA in cerebral cortex were determined.0.9%saline was fed at the dosage of 0.1 ml/100 g for three days preoperatively in the normal control group.SND was fed at the dosage of 0.1 ml/100 g for three days preoperatively in the SND group.Results:The activity of LDH in cerebral cortex was significantly higher in the SND group than in CPR group(P0.01),while the concentration of MDA was markedly lower than those in CPR group(P0.01).The activity of LDH in cerebral cortex were lower in the SND group than in the normal control group(P0.05),while the concentration of MDA was higher than those in the normal control group(P0.01 and P0.05).Conclusions:The results suggest that Sini decoction possiblely play a membrane protective role by suppressing Lipid Peroxidation(LPO) in cerebral cortex and maintaining cells membrane stability after CPR.
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 4 Hits
1 Zhang Yi, Chen Xiao-hui, Jiang Hui-lin, et alThe Second Affiliated Hospital of Guangzhou Medical College, Guangdong Province 510260 PRC;STUDY OF CORRELATION BETWEEM CYTOKINE, OXYGEN FREE RADICAL AND REPERFUSION INJURY AFTER CARDIOPULMONARY RESUSCITATION[J];Modern Hospital;2005-09
2 WU Wei-Kang,HOU Can,LUO Han-Chuan,CHENG Chao,TAN Hong-Mei Department of Pathophysiology,Sun Yat-sen University of Medical Sciences,Guangzhou(510089);Effects of Sini Decoction improving energy metabolism of ischemic myocardium and mechanisms of the effects[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1998-06
3 WU Jun fang, WANG Jie, ZHANG Jun tian (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China);Protective effect of total salvianolic acids against cerebral ischemia reperfusion injuries in mice and rats[J];Chinese Traditional and Herbal Drugs;2001-03
4 Li Youqing, Tan Xiujuan, Xu Qiming, et al. (Department of Anesthesiology, the First Affiliateel Hospital, Hunan Medical University, Changsha 410013.);Effects of sodium ferulate on the contents of TXB_2, 6-keto-PGF_(1a) and MDA in brain tissues after canine cardiac arrest and resuscitation.[J];Chinese Journal of Anesthesiology;1995-09
Chinese Journal Full-text Database 10 Hits
1 Hao Ji-li,Zhou Lan-lan(Department of Pharmacology,Anhui Medical University,Hefei 230032,China);The current study situation and therapy progress of PSD[J];Anhui Medical and Pharmaceutical Journal;2006-07
2 ;Clinical evaluation of the application of exteral fixating framework in severe open fracture of the distal leg[J];Journal of Traumatic Surgery;2005-03
3 LU De-sheng,CHEN Chang-rong,SHAO Xiang,et al.(Department of Emergency,Nanjing Drum Tower Hospital,Medical School of Affiliated Hospital of Nanjing University,Nanjing 210008,China);Coping strategies and methods for mass casualty incidents in Grade Ⅲ-A hospitals:report of the propane explosion event on July 28,2010[J];Journal of Traumatic Surgery;2011-04
4 WANG Xing 1, WANG Zong-Ren 1, WANG San-Hu 2, LI Feng 1, ZHAO Yan-Ling 1, MA Jing 1, LI Jun-Chang 1, WANG Wen 1, LIU An-Heng 3 1Department of Traditional Chinese Medicine, 3Department of Cardiovasology, Xijing Hospital, Fourth Military Medical University, Xi’an 710033, China, 2Traditional Chinese Medicine Hospital of Xi’an, Xi’an 710077, China;Effects of Qidantongmai tablet on LDH and oxygen free radical of cerebral ischemia reperfusion injury in rats[J];Journal of The Fourth Military Medical University;2004-23
5 MA Chun-Hua~1, MU Chun-Xiao~2, LIU Yun~3 ~1Department of Internal Medicine, ~2Department of Immunology and Microbiology, Medical College, Liaodong University, Dandong 118002, China, ~3Department of Traditional Chinese Medicine, Second Affiliated Hospital, Dalian Medical University, Dalian 116023, China;Neuroprotective effect of DanXingTongLuoTang on rats with focal cerebral ischemia-reperfusion injury[J];Journal of the Fourth Military Medical University;2006-21
6 WU Wei-kang, HUANG He-qing, TAN Hong-mei, LUO Han-chuan, LIANG Tian-wen (Institute of Integrated Traditional Chinese and Western Medicine, Sun Yat-sen University of Medical Sciences, Guangzhou 510089, China);The effect of Sini Tang on lipid metabolism and vascular endothelial function in rabbit with experimental atherosclerosis[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;2000-02
7 SHI Gang-rong (Department of Biology,Huaibei Coal Industry Teachers College,235000,Huaibei, Anhui,China);Anatomic Studies on Stem and Leaf of Abelmoschus Manihot[J];Journal of Huaibei Industry Teachers College (Natural Sciences Edition);2003-03
8 SUN Hui-lan, DENG Chun-yu, KUANG Su-juan, WU Wei-kang. Department of Pathphysiology, Zhongshan School of Medicine, SUN Yat-sen University, Guangzhou 510080 China;Effects of Sini Decoction on H_2O_2 induced L-type calcium channel current Changes in rat ventricular myocytes[J];Anatomy Research;2008-01
9 HUANG Ximei LUO Aiping ,et al The first People’s hospital of Zhaoqing,Guangdong 526021,China;Emergencv Treatment to the Sealed Injure of Abdomen[J];International Medicine & Health Guidance News;2004-20
10 WEN Bin∥The People's Hospital of Liuzhou City,Liuzhou 545001,China;Treatment progress on renal trauma[J];Acta Medicinae Sinica;2006-03
Chinese Journal Full-text Database 10 Hits
1 CHEN Wen-shi,LI Ren-zhu (Department of TCM-Integrated,Bengbu Third People's Hospital,Bengbu Anhui 233000,China);Tongqiao blood-activating decoction combined with pancreatic kininogenas for treatment of acute cerebral infarction[J];Journal of Bengbu Medical College;2008-04
2 Zhang Yunke(The First Hospital Affiliated to Henan College of Traditional Chinese Medicine, Zhengzhou 450000);Effect of Buyang Huanwu Decoction and Its Separate Components on Nerve Apoptotic Cells and Protein Expression Level of Bcl-2 and Bax in Brain of SD Rats with Cerebral Ischemical Reperfusion Injury[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-06
3 GUAN Jing-xia~* SUN Sheng-gang YU Shao-zu~*.~*Department of Neurology,People's Hospital of Wuhan University,Wuhan 430060,China;Effect of thrombin on NF-κB activity and ICAM-1 mRNA expression after intracerebral injection in rats[J];Chinese Journal of Neuromedicine;2007-12
4 Li Jun, Zhou Qingzhen, Wang Huamei, et al.Department of Neurology,Yijishan Hospital,Wannan Medical College,Wuhu (241001);Correlationship Between Brain Tissue PAR-1 Expression and MDA Contents in Rat Models of Brain Ischemia-Reperfusion Injury[J];Journal of Radioimmunology;2008-03
5 Guo Jintao1),Gao Tian2),Song Yingfei2).1)Department of Neurology,Puyang People's Hospital,Puyang 457000 2)Department of Neurology,People's Hospital of Shanxi Province,Xi'an 710061,China;Effects of peroxisome proliferator-activated receptor-γ agonist on the levels of cerebral IL-1β,IL-6 and TNF-α in rats experienced focal cerebral ischemia/reperfusion[J];Chinese Journal of Practical Nervous Diseases;2008-02
6 NIE Ya xiong, LI Xing qun, LIANG Qing hua, et al. (Institute of Combined Traditional Chinese Medicine and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China);Protective effect of the serum obtained from rats treated orally with Nao-Yi-An on cultured cortical neurons injured by glutamate[J];Bulletin of Hunan Medical University;2002-05
7 YANG Li-juan1,2, WU Li-xiang1, LIU Fa-yi1, ZHOU Xuan1,HE Fang1, ZHANG Yan1, HUANG Bo-sheng1(1.Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078;2.Department of Physiology,Binzhou Medical Collage, Binzhou Shandong 256603, China);Effect of thrombin on cultured rat cerebral astrocyte injured by hypothia/reoxygenation and its relationship with iNOS[J];Journal of Central South University(Medical Sciences);2007-05
8 LIU Jin-fang1,LIU Yun-sheng1,FANG Jia-sheng1,SHI Bao-zhong2,XU Li-xin3(1.Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha 410008;2.Department ofNeurosurgery,First Affiliated Hospital,Henan University of Science and Technology,Luoyang Henan 471003;3.Department of Neurosurgery,First People's Hospital of Changde,Changde Hunan 415003,China);Thrombin preconditioning reduces brain injury caused by intracerebral infusion of high dose thrombin[J];Journal of Central South University(Medical Sciences);2007-06
9 CHEN Rui-fen1,DENG Chang-qing2,CHEN Bei-yang2,LI Hua21.NO.4 Courtyard Outpatient Department,National Defense Science and Technology University,Changsha,China,410073;2.Hunan University of Traditional Chinese Medicine,Changsha,China,410072;The Effct and Mechanism of Buyang Huanwu Decotion(BYHWD) by Caspase Express After Cerebral Ischemia Reperfusion in Rats[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2009-06
10 Liu Wanghua, Zhang Qiuyan, Li Hua, et al (Faculty of Integrative Medicine, TCM Univ. of Hunan, Changsha, 410007);The Pharmacological Effects of Effective Fractions Extracted from Buyang Huanwu Decoction on the Infiltration of Polymorphonuclear Leukocytes in the Local Cerebral Focus Induced by Ischemia Reperfusion among Rats[J];Journal of Hunan Traditional Chinese Medicine University of Hunan;2003-06
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 CHEN Xiaohui, ZHANG Yi, JIANG HuiLin, et al. Emergency Department, The Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, China;Influences of naloxone on the concentration and expression of lung cytokine after cardiopulmonary resuscitation in dogs[J];Journal of Emergency Medicine;2004-04
2 Pan Xinxin Zhang Minxia. Department of Pharmacology,Nanjing Medical College;Protective Effect of Ginsenosides on Acute Cerebral Ischemia in Rats[J];;1992-03
3 WANG Jie, WU JunFang, ZHANG JunTian(Institute of Materia Medica, Chinese Academy of Medical Sciencesand Peking Union Medical College, Beijing100050);Studies on the anticerebral ischemia effectof total salvianolic acid[J];CHINESE PHARMACOLOGICAL BULLETIN;1999-02
4 WU Jun-Fang;SHI Yi-Ju; LIU Tian-Pei(Department of Pharmacology,Nanjing Medical University,Nanjing 210029;Department of Pharmacology,Tai'an Medical College,Tai'an 271000);Protective effcts of berberine on cerebral ischemia in mice and rats[J];CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY;1995-02
5 LN Xu, WG Yu, JY Tian and QY Liu (Department of Pharmacology, Institute of Materia Medica, Chinese Acadeny of Medical Sciences, Beijing 100050 );EFFECT OF SODIUM FERULATE ON ARACHIDONIC ACID METABOLISM[J];Acta Pharmaceutica Sinica;1990-06
6 YS Huang;JT Zhang Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050;ANTIOXIDATIVE EFFECT OF THREE WATER-SOLUBLE COMPONENTS ISOLATED FROM SALVIA MILTIORRHIZ A IN VITRO[J];Acta Pharmaceutica Sinica;1992-02
7 A CH Du,Y QiU,YE Tian and JT zhang(Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050;Beijing Traditional Chinese Medicine Hospital, Beijing 100010);PREVENTON OF GALACTOSE-INDUCED CATARACTOGENESIS IN RATS BY SALVIANOLIC ACID[J];ACTA PHARMACEUTICA SINICA;1995-08
8 Chen Zhiwu(Chen ZW), Ma Chuangeng(Ma CG) and Zhao Weizhong(Zhao WZ)(Department of Pharmacology, Anhui Medical University, Hefei 230032);PROTECTIVE EFFECT OF HYPERIN AGAINST CEREBRAL ISCHEMIAREPERFUSION INJURY[J];ACTA PHARMACEUTICA SINICA;1998-01
9 Wu Wei-Kang;Hou Can, et al Department of Pathophysiology, Sun Yat-Sen University of Medical Sciences, Guangzhou;Pituitrin-induced myocardial ischemia——a model for screening oxy-radical scavenger in mice[J];Chinese Journal of Pathophysiology;1993-02
10 Wu Weikang; Luo Hanchuan; Hou Can(Department of Pathophysiology, Sun Yat-sen University of Medical Sciences, Guangzhou 510089)Mei Ningyi, Zhang Jianhui(Central Lab, Chemical Faculty, Zhong Shan University, Guangzhou 510275);AGED HEART AND STRESS-INDUCED FREE RADICAL INJURY[J];CHINESE JOURNAL OF APPLIED PHYSIOLOGY;1994-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved