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《Journal of Bengbu Medical College》 2012-05
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The study of thinprep cytology test combined truscreen in early diagnosis cervical precancerous lesions

ZHANG Xiao-peng,LUO Xin,WANG Xiao-yu(Department of Gynecology and Obstetrics,The First Affiliated Hospital of Jinan University,Guangzhou Guangdong 510632,China)  
Objective:To investigate the application value of thinprep cytology test(TCT) combined truscreen(TS) in early diagnosis cervical precancerous lesions. Methods:Thirty patients with abnormal vaginal secretions were detected under TCT and TS,and then vaginal tissue biopsies were tested under colposcopy.The results of pathological examination acted as the gold standard of diagnosis.The match degrees of single and combined using methods and histopathological examination results were compared. Results:The results of histopathological examination of 25 cases were cervical intraepithelial neoplasia grade 1 or above.Nineteen cases(63.3%) were ASCUS cytology positive,6 cases were false negative,16 cases were true postive,the rate of fail to diagnosis was 20.0%,and the sensitiveness degree was 84.2% under TCT.Compared with TCT results,the data were 18 cases(60.0%),7 cases,14 cases,23.3% and 77.8% under TS respectively.Compared with TCT or TS results,the data were 27 cases(90.0%),1 case,24 cases,3.3% and 88.9% under TCT and TS respectively.The positive rates of pathology examination and TCT combined with TS inspection was 90.0% and 83.3% respectively,the difference had not statistical significance(P0.05). Conclusions:The accuracy of TCT combined with TS inspection for diagnosing cervical precancerous lesions is better than any one single examination,and its rate of fail to diagnosis declined significantly.
【Fund】: 国家自然科学基金资助项目(30770487)
【CateGory Index】: R737.33
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