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《ACTA ACADEMIAE MEDICINAE BENGBU》 1997-03
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Effect of lipid peroxidation in benzene in halation of mice

Wang Chunhua,Xiao Di,Zhao Hong,Ge Ping (Department of Hygiene,Bengbu Medical College,Anhui 233003 )  
Objective:To study the effect of MDA,SOD,GSH Px after benzene inhalation in mice,for seeking a parameter of early detecton.Methods:Mice were divided at random into 3 experimental groups and a control group.Static inhalation of benzene in concentration of 1/8 LC 50 ~1/128 LC 50 were given to mice of the experimental group 2 h every day for 30 days.White count,concentration of MDA,SOD,and GSH Px in blood were detected, F and q tests were calculated for comparison.Results:In the experimental mice,the white counts were within normal range,MDA contents increased with the concentration and duration of benzene inhaled( P 0.05),SOD activities increased with increase in concentration( P 0.05),but not with duration of benzene inhalation,GSH Px activities decreeased,on the contrary,as the concentration and duration( P 0.05).Conclusions:The results indicate that the changes in activities of MDA,SOD and GSH Px may reflect the benzene in toxication,which is significant for early detection in benzene workers.
【CateGory Index】: R135.1
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