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Regulation of basic fibroblast growth factor receptors

Jiang Zhiwen (Department of Pharmacology,Bengbu Medical College,Anhui 233003 )  
Objective:To examine the influence of transforming growth factor β 1(TGFβ 1) and ACTH on basic fibroblast growth factor(bFGF) receptors of bovine adrenocortical fascilata reticularis cells (BAC cells).Methods:BAC cell culture in primary condition; 125 I bFGF receptor specific binding labeling;Scatchard analysis.Results:High and low affinity receptors were identified,for the cells that were treated with TGFβ 1(2 ng/ml),high and low affinity bFGF receptors were 6 500 sites/cell(K D=3.1511×10 -11 mol/L) and 140 000 sites/cell(K D=1.627 7×10 -9 mol/L) respeectively.For the cells that were treated with ACTH(3.0×10 -7 mol),high and low affinity bFGF receptors were 7 600 and 95 000 sites per cell respectively(K D=3.609 8×10 -11 mol/L and K D=1.401 2×10 -9 mol/L correspondingly).Conclusions:The number of bFGF receptors was increased under the influence of TGFβ 1 and ACTH,a detectable difference in strenth and selectivity was observed.The difference in effects on BAC cells may be due to their difference in biological activities between TGFβ 1 and ACTH.
【CateGory Index】: R322.5
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