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《JOURNAL OF BENGBU MEDICINAE COLLEGE》 1998-03
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p53 expression in benzene inhalation of mice

Wang Chunhua,Zhou Qihong,Cheng Zenong,Zhao Hong,Xiao Di,Ge Ping(Department of Hygiology,Bengbu Medical College,Anhui 233003)  
Objective:To study the toxicity of benzene inhalation on DNA of bone marrow cells in mice.Methods:After static inhalation of benzene for 30 days,bone marrow cells were tested for p53 by using immunohistochemical technic,and u test is calculated for comparison with the control group.Results:All experimental mice all survived,their white cells counts were within normal range.p53 expression of the highest concentration inhaling group(3.96 mg/L) was higher than that of the control and the other experimental groups(P0.01 and P0.05).Conclusions:Inhalation of benzene effects DNA of bone marrow cells.This may be one of causes of leukemia.
【Fund】: 蚌埠医学院科研基金
【CateGory Index】: R730.231.1
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