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《ACTA ACADIMAE MEDICINAE QINGDAO》 2000-01
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AN EXPERIMENTAL STUDY ON CORNEAL NERVE DAMAGE AND REGENERATION AFTER EXCIMER LASER PHOTOREFRACTIVE KERATECTOMY FOR HIGH MYOPIA

JIANG Tao,WANG Chuanfu,LIU Meiguang, et al\ Department of Ophthalmology,The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003\; [  
Objective\ To observe the morphological changes and ultrastructural organization of corneal nerve damage and regeneration after excimer laser photorefractive keratectomy (PRK) for high myopia, and evaluate the morphological basis for the changes in corneal sensitivity and the correlation with haze.\ Methods\ 24 white rabbits were used.A one pass three zone technique was used to correct high myopia (-15.00D) in left eyes, and right eyes were used as control.Light micrography (acetylcholinesterase staining) and electron micrography were used to demonstrate morphological features in rabbit corneal nerves at 1 day, 3 days, 10 days,30 days,90 days and 180 days after PRK.\ Results\ At 1 or 3 days after PRK, the subepithelial nerve plexus and stromal nerve trunks didn't regenerete in high myopia group. At 10 days, some regenerating nerves within the treated area in epithelial and subepithelial layers were visualized in high myopia group.30 days after PRK the density of regenerative fibrils in epithelial layer in high myopia group was higher than that of normal and peaked at 90 days after PRK. In high myopia group 30 days after PRK, new regenerating stromal nerves sprouting was detected. Nerve regeneration had not completed in the central cornea in high myopia group at 180 days after PRK. Electron micrography showed abnormal ultrastructure of corneal nerves at 30,90 and 180 days after PRK, such as decrease of neurofilaments and swollen mitochondria.\ Conclusion\ PRK for high myopia can excise stromal nerve trunks. Stromal nerve regeneration is slower and ultrastructure of nerves is abnormal. The recovery of corneal sensitivity needs a long term. Haze in high myopia group after PRK being more intense may be related to the damage of corneal stromal nerve trunks. [
【CateGory Index】: R779.63
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