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《ACTA ACADIMAE MEDICINAE QINGDAO》 2000-01
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THE EFFECTS OF NIMOTOP ON APOPTOSIS AFTER FOCAL CEREBRAL ISCHEMIA FOLLOWED BY REPERFUSION

WANG Chunxia,ZHAO Renliang, BAO Shiyao, et al Department of Neurology, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042; [  
Objective To investigate the effect of nimotop(NM) on apoptosis after focal cerebral ischemia followed by reperfusion and thus provide more theoretical basis for clinical application of nimotop for the treatment of ischemic cerebrovascular diseases. Methods Rats were pretreated with NM(500μg/kg) 30min prior to MCAO,changes of protein expression of c fos and bcl 2 in rats after ischemia and reperfusion were observed by immunohistochemical method. Results The infarct volume in NM group was significantly smaller than that in the corresponding regions in the control group(t=2.79,P0.05).In NM group,the protein expression of c fos decreased significantly after ischemia/reperfusion both in the ischemic cortex and in the ischemic basal ganglia(t=4.84,6.14,P0.001),but the protein expression of bcl 2 increased significantly after ischemia/reperfusion both in the ischemic cortex and in the ischemic basal ganglia (t=3.53,4.22, P0.001). Conclusion NM may inhibit the development of apoptosis in rats after ischemia and reperfusion and have the neuro protective effect against ischemia. [
【CateGory Index】: R965
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