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《Acta Acadimae Medicinae Qingdao》 2001-01
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THE PROTECTIVE EFFECT OF TAURINE ON NEURAL TRANSPLANTATION OF FETAL MESENCEPHALON CELLS

LIU Tianwei, XIE Junxia \ Cerebrolvascular Disease Institute, Qingdao University Medical College, Qingdao 266021\; [  
Objective\ To study the effect of taurine on the living and growth of transplanted cells in Parkinson disease (PD) rat models after fetal mesencephalon cells transplantation. \ Methods\ The rat models of hemiparkinsonism were prepared with 6 hydroxydopamine (6 OHDA). Cell suspension of ventral mesencephalic (VM) tissue of fetal rats or normal saline (NS) (control group) was stereotaxicly transplanted into striatum of lesioned side of the rat models. NS or taurine was injected into the intracerebral ventricle of the PD rat models transplanted with VM. Fifty six days later, using immunohistochemical staining technique of tyrosine hydroxylase (TH), we observed the living and growth of dopaminergic (DA) neurons (TH positive cells) in striatum of the rat models. \ Results\ Survival transplanted dopaminergic neurons could be observed in striatum of lesioned side of PD rat models after fetal mesencephalon cells transplantation. The number of dopaminergic neurons after treatment with taurine was extremely higher compared with those treatment with NS ( F=508.5,q=3.9,P 0.01). While dopaminergic neurons could not be observed in striatum of lesioned side of the control rat models. \ Conclusion\ Taurine could efficiently improve the living condition of transplanted cells and promote them to grow. [
【Fund】: 卫生部优秀青年科技人才专项科研基金!( 96Q 0 85 ) ;; 国家“九五”科技攻关计划!(NO .96 90 6 0 5 0 8)资助项目
【CateGory Index】: R742.5
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