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《Acta Acadimae Medicinae Qingdao》 2001-01
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A STUDY OF THE CONTENT OF DNA AND RNA IN HYDATIDIFORM MOLE AND ITS RELATION WITH MALIGNANT TRANSFORMATION

CHI Jinghua,JI Xiangrui,ZHANG Hua, et al\ Department of Pathology, Qingdao University Medical College, Qingdao 266021[  
Objective\ To study the relationship of DNA and RNA content with malignant transformation in hydatidiform mole(HM) and find out a method for predicting the transformation. \ Methods\ DNA,RNA content was detected by image analysis technique in 100 cases of HM,and 20 cases of malignant mole and choriocarcinoma were used for comparison. \ Results\ DNA,RNA content in malignant cases was significantly higher than that in HM (t'=4.68,t=8.39,P 0.01).There was significant difference between complete and partial HM (t'=3.08,4.48,P 0.01).DNA,RNA content in completely malignant transformed HM was significantly higher than that in non malignant transformed HM cases (t'=4.77,5.06,P 0.01).\ Conclusion\ Detecting DNA and RNA content of HM tissues by image analysis technique can predict the malignant transformation of HM. [
【CateGory Index】: R737.33
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