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《Acta Acadimae Medicinae Qingdao》 2002-02
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YAN Yinfang, CHEN Xiao, YANG Xiaoqing, et al\ The Institute of Virus Research, The Basic Medical College of Wuhan University, Wuhan 430071\;  
Objective\ To identify and determine the antivirus active ingredients of volatile oil of Mosla Chinensis Maxim(MCMVO) for influenza virus type 3 in vitro and in vivo.\ Methods\ The components of MCMVO were separated by silica gel chromatography. A study on antivirus active components of MCMVO was carried out using CPE inhibition and antiviral activities of active components were assessed further by white mouse model of influenza virus pneumonia.\ Results\ MCMVO, neural MCMVO and the eluent ( C ingredient) separated by silica gel chromatography had antiviral activities against influenza virus. The antiviral activity of C ingredient was the highest. The therapeutic indexes were 35.0, 36.9 and 70.9, respectively. The therapeutic effect of MCMVO and the C ingredient was significant for influenza virus pneumonia of mice when the dose given was 100 mg/kg bodyweight or more.\ Conclusion\ The antivirus active components may exist in the C ingredient separated by silica gel chromatography.
【CateGory Index】: R285.5
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