Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Acadimae Qingdao Umvesitatis》 2003-03
Add to Favorite Get Latest Update

RELATIONSHIP BETWEEN VNTR POLYMORPHISM OF PLATELET GLYCOPROTEIN Ⅰb GENE AND CEREBRAL INFARCTION

TENG Ji jun\ (Department of Neurology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China)\;  
Objective\ To investigate the distribution of alleles and genotypes of GPⅠb gene VNTR polymorphisms in Chinese population of Qingdao areas and the relationship between these polymorphisms and cerebral infarction(CI).\ Methods\ In this study, PCR was applied to analyze 105 patients with CI, confirmed by brain CT and/or MRI, and 100 age and sex matched controls without clinical evidence of CI for their alleles and genotype frequencies of the VNTR polymorphism.\ Results\ The B allele frequency and the BC genotype of GPⅠb gene VNTR polymorphism were significantly higher in the CI group than in the control group ( χ 2=5.162,4.386; P 0.05). Logistic regression analysis revealed that the presence of VNTR B allele was frequently associated with CI ( OR =5.10, P =0.046, 95% CI =0.96-27.15). \ Conclusion\ The platelet GPⅠb gene VNTR polymorphism is associated with CI, and BC genotype and B allele might be genetic risk factors for CI.
【CateGory Index】: R743.33
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 CUI Lan-ying,XIN Xiao-min,ZHAO Yu,et al(Department of Laboratory Diagnosis,The First Clinical College,Harbin Medical University,Harbin 150001,China);The distribution of VNTR polymorphisms of the platelet membrane glycoprotein 1b α in Harbin Han nationality[J];Journal of Harbin Medical University;2006-04
2 WANG Yao,XIN Xiao-min,LI Xiao-yang,et al.Clinical Laboratory of Beijing Chaoyang Hospital,Beijing 100043,China;Relationship of VNTR Polymorphism of Platelet Glycoprotein I bα to Aspirin Resistance[J];Chinese General Practice;2010-08
3 XIN Xiao-min ZHAO Yu CUI Lan-ying Department of Laboratory Diagnosis,the First Clinical College,Harbin Medical University,Harbin 150001,China;The distribution of platelet glycoprotein I bα variable number tande repeat polymorphism and the relationship with cerebral infarction[J];Chinese Journal of Laboratory Medicine;2007-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHU Wei-Quan WANG Yi-Quan(Institute of Genetic Resources, College of Life Science, Nanjing Normal University, Nanjing 210097, China);AFLP and Its Application in Zoological Research[J];Chinese Journal of Zoology;2003-02
2 Bao Lei Niu Cuijuan(Ministry of Education Key Laboratory of Biodiversity Science and Ecological Engineering;College of Life Sciences: Beijing Normal University,100875,Beijing,China);THE USE OF RANDOMLY AMPLIFIED POLYMORPHIC DNA ANALYSIS TO STUDY GENETIC STRUCTURE OF THE ROTIFER BRACHIONUS QUADRIDENTATUS[J];Journal of Beijing Normal University(Natural Science);2007-01
3 Xia Qingyou;Zhou Zeyang;Lu Cheng; Feng Llchun; Xiang Zhongh ai(The SericuItural Key Laboratory of Ministry of of griculture,College of Sericulture & Silk,Southwest Agricultural University,Chongqing 6307l6,China);A STUDY ON CONDITIONS,AND REPEATABILITY AND INHERITANCE PATTERN OF RANDOM AMPLIFICATION POLYMORPHIC DNA(RAPD)IN F1 OF SILKWORM(BOMBYX MORI.)[J];ACTA SERICOLOGICA SINICA;1996-01
4 CHEN Fu~(1,2),FAN Yan~2,QIN Hua~1(1.College of Horticulture and Landscape,Southwest University,Chongqing 400716,China;2.Chongqing Animal Husbandry Science Research Institute,Chongqing 400039,China);Study on influencing factors of RAPD in Hemarthria compressa[J];Pratacultural Science;2006-09
5 Zhang Kezhong, Jia Yuehui(Department of Landscape Architecture, Beijing Agricultural College, Beijing 102206, P. R. China); Zhang Qixiang, Wang Jieqiong(Beijing Forestry University);Genetic Relationship among Several Wild Lilies Native to China via AFLP Technique[J];Journal of Northeast Forestry University;2008-02
6 BIAN Chun-yuan, DONG Shi, TAN Shu-zhen(College of Chemistry and Biology,Tianjin Normal University,Tianjin 300387,China);PCR-RFLP analysis of mtDNA D-loop region of three populations of bluntnose blackbream Megalobrama amblycephala[J];Journal of Dalian Fisheries University;2007-03
7 SONG Xian-liang~(1,2), SUN Xue-zhen~1, ZHANG Tian-zhen~2, WANG Hong-gang~(1*)(1 Agronomy College of Shandong Agricultural University,Tai’an,Shandong 271018,China;2 National Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095,China);Advances on genetic diversity of cotton (Gossypium)[J];Acta Botanica Boreali-occidentalia Sinica;2004-12
8 Zhong Shounan (Wuhan University of Hydraulic and Electric Engineering,Wuhan 430072);PRINCIPLE OF THE NATURAL EVOLUTION IS GOOD ENLIGHTENMENT TO SYSTEMATIC OPTIMIZATION[J];EXPLORATION OF NATURE;1998-01
9 Wang ZhonghuaInstitute of Biotechnology, Zhejiang Wanli University, Ningbo, 315100;DNA Fingerprinting Technology and its Application in Crop Germplasm Resources[J];Molecular Plant Breeding;2006-03
10 LAO Fang-ye,LIU Rui,HE Hui-yi,DENG Hai-hua,CHEN Zhong-hua,CHEN Jian-wen,FU Cheng,ZHANG Chui-ming(Guangzhou Sugarcane Industry Research Institute/Guangdong Key Lab of Sugarcane Improvement and Biorefinery,Guangzhou 510316,China);Genetic diversity of introduced sugarcane varieties assessed by AFLP analysis[J];Guangdong Agricultural Sciences;2008-04
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 CAO Yi-hong.Department of Medicine,Wuxing Hospital of Intergrative Chinese and Western Medicine,Huzhou 313000,China;Aspirin Resistance in the Elderly Patients with Coronary Artery Disease and Its Associated Clinical Factors[J];Chinese General Practice;2010-34
2 CHEN Xiao-yan,LIANG Jian-wen,HU Xue-song,et al.(The People's Hospital of Futian District,Shenzhen 518033,Guangdong,China);Clinical Significance of Detection of Platelet Aggregation Ratio in Patients Undergoing Percutancous Coronary Intervention[J];Practical Preventive Medicine;2012-07
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved