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《Acta Acadimae Qingdao Umvesitatis》 2003-03
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TENG Ji jun\ (Department of Neurology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China)\;  
Objective\ To investigate the distribution of alleles and genotypes of GPⅠb gene VNTR polymorphisms in Chinese population of Qingdao areas and the relationship between these polymorphisms and cerebral infarction(CI).\ Methods\ In this study, PCR was applied to analyze 105 patients with CI, confirmed by brain CT and/or MRI, and 100 age and sex matched controls without clinical evidence of CI for their alleles and genotype frequencies of the VNTR polymorphism.\ Results\ The B allele frequency and the BC genotype of GPⅠb gene VNTR polymorphism were significantly higher in the CI group than in the control group ( χ 2=5.162,4.386; P 0.05). Logistic regression analysis revealed that the presence of VNTR B allele was frequently associated with CI ( OR =5.10, P =0.046, 95% CI =0.96-27.15). \ Conclusion\ The platelet GPⅠb gene VNTR polymorphism is associated with CI, and BC genotype and B allele might be genetic risk factors for CI.
【CateGory Index】: R743.33
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