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《Acta Acadimae Qingdao Umvesitatis》 2003-03
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ZHANG Min, ZHANG Hui \ (Department of Pathology, Qingdao University Medical College,Qingdao 266021, China)\;  
Objective\ To study the effect of β aescinate on NO metabolism in acute ischemia and ischemia reperfusion model of rat brain. \ Methods\ The acute ischemia and ischemia reperfusion model of rat brain was induced by blocking of four vessels. The rats were divided into seven groups: control group; 30 minute global ischemia group; 30 minute global ischemia+drug group; 30 minute global ischemia and 30 minute reperfusion group; 30 minute global ischemia and 30 minute reperfusion +drug group; 30 minute global ischemia and 5 day reperfusion group; 30 minute global ischemia and 5 day reperfusion group. β aescinate (10 mg/kg, iv) was injected before operation. The changes of the contents of NO, MDA and SOD in the cortex and serum were observed.\ Results\ Compared with the rats in the drug group, those in the ischemia group and ischemia reperfusion group showed a significant increase in concentrations of NO and MDA in the cortex and serum ( F=18.51-123.66, q=5.41- 29.59 , P 0.01), but a significant decrease in the level of SOD ( F=5.87, q=4.81-26.02, P 0.05). \ Conclusion\ β aescinate may influence NO metabolism and protect the neuron cells by means of anti free radicals.
【CateGory Index】: R741
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2 Zhou Xiuli,Zeng Guangwei,Li Shikun.Department of Neurology,Xinyang Central Hospital,Xinyang 464000,China;Study of β-aescinate's neuron protection on perihematoma after intracerebral hemorrhage in rats[J];Chinese Journal of Practical Nervous Diseases;2008-04
3 LI Yun.Medical College of Yan′an University,Yan′an,Shanxi 716000,China;Effect of β-aescinate sodium on blood-brain barrier permeability and GFAP expression after cerebral ischemia and reperfusion injuries in rats.[J];Sichuan Medical Journal;2010-10
4 WANG Hang-hui1,ZHANG Bo2,ZHU Wen-xia1,et al.1.Medical College of Yan'an University,Yan'an,Shanxi 716000;2.Medical College of Huzhou Teachers College,Huzhou,Zhejiang 313000,China;Effects of exnotransplantation of microencapsulated olfactory bulb combined with β-aescinate sodium on blood-spinal barrier function and vasogenic spinal cord edema in spinal cord injury rats[J];Sichuan Medical Journal;2011-03
5 ZHOU Qing-bo1,BI Jian-zhong1,LI Lu-yang2,SHAO Nian-fang3,JIA Qing4(1.Department of Neurology,Second Hospital of Shandong University,Jinan 250033,Shandong,China; 2.Department of Traditional Chinese Medicine,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China; 3.Department of Amergency,Affiliated Hospital of Shandong Traditional Chinese Medicine University,Jinan 250012,Shandong,China; 4.Instifute of Preclinical Medicine,Shandong of Medical Sciences,Jinan 250012,Shandong,China);Effect of β-aescinate on changes of superoxide dismutase,nitrogen monoxide and tumor necrosis factor-α content in blood after intracerebral hemorrhage in rats[J];Journal of Shandong Univenity(Health Scicnes);2005-01
6 Wang Hanghui,Zhu Wenxia,Li Xiaoji,Han Zhenkui,Wang Lu,Zhao Lin,Liu Bofeng(Department of Anatomy,Medical College of Yanan University,Yan’an 716000,China);Combining exnotransplantation of microencapsulated olfactory bulb and drug intervention to repair the injured spinal cord[J];Chinese Journal of Neuroanatomy;2010-06
7 SUN Chen-you1, FANG Zhou-xi2, QI Shuang-shuang3, SUN Shu-hong1, ZHOU Peng1, CUI Huai-rui1, TANG Mao-lin1(1Department of Anatomy, 2Department of Electron Microscopy, Wenzhou Medical College, Wenzhou 325035, China; 3Department of Pharmacy, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China.);Effect of curcuma aromatica oil on learning,memory and hippocampal p-CaMKII expression in rats exposed to chronic hypoxia[J];Chinese Journal of Pathophysiology;2008-11
8 HAN Dong,YANG Yi-min,DENG Fang,et al. (Department of Neurology,First Hospital of Jilin University,Changchun 130021,China);Effect of sodium aescinate on the permeability of blood-brain barrier in rats after cerebral ischemia-reperfusion[J];Journal of Apoplexy and Nervous Diseases;2008-03
9 GUO Jin lan, ZHANG Cheng bo.Chinese Rehabilitation Medicine Research Institute, Beijing 100068, China;Protective effects of the compound with low molecular weight of anti-free radical on brain injury in rats[J];Chinese Journal of Rehabilitation Theory & Practice;2004-07
10 ZHOU Qing-Bo, LI Lu-Yang, BI Jian-Zhong, et al. Department of Neurology, Second Affiliated Hospital of Shandong University, Jinan 250033, Shandong, China;Study of β-aescinate on protective mechanism of inflammatory injury after intracerebral hemorrhage in rats[J];Chinese Journal of Gerontology;2006-01
Chinese Journal Full-text Database 10 Hits
1 WANG Yuan jing,FANG Zheng qing,LEI Li,BAI Mei (Dept.of Integrated Traditional and Western Medicine, Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China);INFLUENCES OF TONGNAOJING CAPSULE ON THE CONTENTS OF NITRIC OXIDE AND TUMOR NECROSIS FACTOR-ALPHA IN INSULIN RESISTANCE RATS AFTER LOCAL CEREBRAL ISCHEMIA[J];Journal of Anhui Traditional Chinese Medical College;2002-03
2 Shao Nianfang (Affiliated Hospital of Shandong College of TCM , Shandong);On Syndrome of Hollow Viscera in Apoplexy[J];;1988-06
3 GONG Biao,LI Chang-qing,HUANG Jian(1.TCM College Chongqing University of Medical Sciences,Chongqing 400050,China;2.Second Hospital Affiliated to Chongqing University of Medical Sciences,Chongqing 400010,China);Modification of suture methods for rat model of focal cerebral ischemia/reperfusion[J];Chongqing Medicine;2006-04
4 PAN Feng,CHEN An-min,ZHU Chen-liang,et al.(Department of Orthopaedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China);Comparative study on two hindlimb behavior evaluation systems following moderate spinal cord injury in rats[J];Journal of Traumatic Surgery;2008-02
5 ;Progress in the Treatment of Spinal Cord Injury[J];;2000-01
6 TU Qiu-yun, TANG Xiang-qi, LI Xiao-bo,et al. Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha 410013, China;The Expression of ET-3 and GFAP in the Layers Ⅲ-Ⅵ of Frontal and Parietal Lobes of Mice Following Cerebral Ischemia/Reperfusion[J];Journal of Chinese Physician;2003-12
7 LIN Yong-zhong,WANG Nai-chang,NIE Zhi-yu (Department of Neurology,the Second Affiliated Hospital,Dalian Medical University,Dalian 116027,China);The preventive effects of MgSO_4 during cerebral ischemia-reperfusion[J];Journal of Dalian Medical University;2001-01
8 HUANG Yi, XIONG Li Ze, YANG Jing ,JI Gen Lin,NIE Huang Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xian 710033, China;Protective role of β-aescinate against focal cerebral ischemia in rats[J];Journal of The Fourth Military Medical University;2004-04
9 LIU Jia-lan, LI De-qing, DUAN Xian-yu(Experimental Center, Medical College of Hubei Institute for Nationalities, Enshi, 445000, China);Protection of Panax Japonicus Extract Against Mice and Rats Cerebral Ischemia Reperfusion Injury[J];Journal of Hubei Institute For Nationalities Medical Edition;2002-01
10 Lei Wanglong, Liu Yong 1, Yao Zhibin, Yuang Qunfang, Lin Fengdong 1 (Department of Anatomy, Sun yat sen University of Medical Sciences, Guangzhou,510089 1\ Department of Anatomy, Xi'an Medical University, Xi'an 710061 China);A STUDY OF ICAM-1 EXPRESSION AND LFA-1 POSITIVE CELL INFILTRATION IN ISCHEMIC BRAIN ISCHEMIA IN RATS[J];CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY;2000-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 HU Yu1,CHEN Hao-fan1,ZANG Lin-quan2,WU Wei2(1.The General Hospital of Police of Guangdong Province,Shenzhen,Guangdong 518029,China;2.School of Pharmacy/New Discovery Center,Guangdong College of Pharmacy,Guangzhou,Guangdong 510006,China);Protective effects of ginsenoside Rb_3 on focal cerebral ischemic injury in rats[J];Journal of Guangdong College of Pharmacy;2008-06
2 Dai Quande,Zhang Jianping,Lu Wenge,et al.Department of Neurology ,the First People's Hospital of Shangqiu,Shangqiu 476100,China;The relationship of apoptosis of cerebral tissue and cytochrome C expressions in perihematomal region in intracerebral hemorrhage patients[J];Chinese Journal of Practical Nervous Diseases;2009-07
3 JUE LI-li,YU Zi-jiang;Review on present research of treating spinal cord injury by transplantation of olfactory ensheathing cells[J];Journal of Regional Anatomy and Operative Surgery;2012-02
4 CUI Xiao,LI Xiao-bin,DONG Rui-guo,et al.Xuzhou Medical College,221000 Xuzhou,China;Curative effect of β-sodium aescinate therapy on cerebral edema after acute cerebral infarction[J];Journal of Clinical Neurology;2012-01
5 BAO Cui-fen1,2,LIU-Xia2,LIANG-Jia2,WEI-Jia2,QIN Shu-jian1,2(1.Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China; 2.Liaoning Medical College,Jinzhou 121001,Liaoning,China);Effects of Ginsenoside Rg1 on Expressions of Fas Caspase-3 in Brain Tissue after Cerebral Arterial Thrombosis in Rats[J];Journal of Liaoning University of Traditional Chinese Medicine;2009-05
6 ZHANG Bo,HU Ting-ting,ZHANG Ping,CHEN Xiao-Jun,CHEN Ling-Bo,SUN Shuang(Medical College of Huzhou Normal College,Huzhou 313000,Zhejiang,China);Influence of Bcl-2/Bax Expressions and the Apoptosis of Motor Neuron in Spinal Cord Injury after Using Erythropoietin[J];Journal of Liaoning University of Traditional Chinese Medicine;2012-10
7 Zhu Wenxia1,Wang Hanghui2,Han Zhenkui1 (1.Medical College of Yan'an University,Yan'an 716000;2.Shanghai Jiao Tong University School of Medcine,Shanghai 200025,China);Study on repair of spinal cord injury of rats by heterotransplantation of microencapsulated ensheathing cells combined with China herb[J];Chinese Journal of Neuroanatomy;2011-06
8 SUN Chen-You1,*, HU Wei2, QI Shuang-Shuang2, DAI Kai-Yu1, HU Si-Wang1, LOU Xin-Fa1 1Department of Anatomy, Wenzhou Medical College, Wenzhou 325035, China; 2Department of Pharmacy, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China;Effect of Rhizoma curcumae oil on the learning and memory in rats exposed to chronic hypoxia and the possible mechanisms[J];Acta Physiologica Sinica;2008-02
9 LIU Li-juan1,ZHOU Hong-hao2 (1,2 Institute of Clinical Pharmacology,Central South University,Changsha 410078,Hunan,China);Pharmacological effects of aescin and its clinical application[J];Progress in Modern Biomedicine;2010-05
10 MA Ban-you△,WANG Shou-hai,ZHOU Ji-ye,SHI Ging,HE Gui-zhi,WANG Yu-xia(Fourth People's Hospital of Changzhou affiliated to Suzhou University,Neurosurgery,213001,Changzhou,China);Protection and prognosis effect of scopolamine on severe brain injury[J];Progress in Modern Biomedicine;2010-21
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