Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Acadimae Qingdao Umvesitatis》 2004-01
Add to Favorite Get Latest Update

EXPRESSION OF P21~(CIP1) AND P53 PROTEINS IN MALIGNANT TRANSFORMATION OF HYDATIDIFORM MOLE

CHI Jing-hua, JI Xiang-rui (Department of Pathology, Qingdao University Medical College, Qingdao 266021, China);  
Objective To compare the differences of P21 CIP1 and P53 protein expressions in hydatidiform mole, malignant mole and choriocarcinoma, and to provide experimental basis for the involvement of P21 CIP1 and P53 proteins in the cell cycle regulation in these tumors. Methods A SABC immunohistochemical technique was used to detect the expression of P21 CIP1 and P53 proteins in 100 cases of hydatidiform mole specimens and 20 cases of malignant mole and choriocarcinoma tissue. Results The P21 CIP1 and P53 protein expressions in hydatidiform mole specimens showed significant difference(χ 2=5.02, P0.05); while in malignant mole and choriocarcinoma tissue, no significant difference was found (P=0.47). Conclusion P21 CIP1 and P53 protein expressions in hydatidiform mole affected each other, but not in malignant mole and choriocarcinoma. P21 CIP1 protein expression may be induced by wild-type P53, not by mutation-type one.
【CateGory Index】: R737.33
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 Zhang Xiaoli1,2,Shi Yuhua2,Zhang Qingli3,Wu Yuling1,Bing Lujun1,Chen Zijiang2(1Center of Reproductive Medicine,Shandong Provincal Hospital,Shandong University,Jinan 250021;2Department of Histology and Embryology,Medical School,Shandong University,Jinan 3Morphological Laboratory,Medical School,Shandong University,Jinan 250012,China);EXPRESSION OF ONCOGENE p_(21) IN THE COMPLETE HYPDATIDIFORM MOLE AND NORMAL PLACENTA[J];Chinese Journal of Histochemistry and Cytochemistry;2008-03
【Citations】
Chinese Journal Full-text Database 2 Hits
1 YANG Li Jun 1, SHAO Guo Xing 1, LIU Rong Fu 2, WANG He 1, CHEN Bao Qi 1 1Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710033, China, 2Department of Urology, Tangdu Hospital, Fourth Military Medic;Expression and correlation of P21~(CIP1/WAF1) , Rb in human prostate cancer[J];Journal of The Fourth Military Medical University;2001-12
2 Chi Jinghua,Ji Xiangrui.Department of Pathology,Medical College of Qingdao University,Qingdao 266021;Relationship between the p53,p21~(CIP1),p185 protein expression and malignant transformation in hydatidiform mole[J];Current Advances In Obstetrics and Gynecology;2003-04
【Co-references】
Chinese Journal Full-text Database 5 Hits
1 Huang Xiuqin 1,Ruan Yonghua 2,Liu Baoyuan 2,Zhang Huaxian 2 ( 1Department of Histology and Embryology, 2Department of Pathology, Kunming Medical College,Kunming 650031);STUDY OF N-RAS IN SITU HYBRIDIZATION ON TROPHOBLASTIC TUMOR[J];Chinese Journal of Anatomy;2001-04
2 Li Qiling; Liu Huixi. (The First Affiliated Hosptal of Xian Medical University,Xian 710061);The expression and clinical benefit of p21 in the trophoblast gestational discase[J];SHAANXI ONCOLOGY MEDICINE;1999-03
3 Liu Yuling,Cui Jinquan,Li Xiaomei,et al.The Affiliated Second Hospital,Henan Mectidcal Mecidcal University,Zhengzhou,450003.;H-ras and C-myc gene expression in normal human placenta and in hydatidiform mole trophoblast.[J];CHINESE JOURNAL OF PRACTICAL GYNECOLOGY AND OBSTETRICS;1998-04
4 Zeng Qingbiao Wang Zhenguo Gan Runliang et alDepartment of Pathology, First Teaching Hospital of Hengyang Medical College, Hunan Province;C-Ha-ras Gene Mutation and p21 Expression in Gestational Trophoblastic Disease[J];CHINESE JOURNAL OF CLINICAL ONCOLOGY;2000-02
5 Hui Jing Pan Yanluo Han Yingjie et al Department of Pathology, Tianjin Medical University, Tianjin;Proliferative State and p21~(WAFI/CIPI) Expression in Placental Site Trophoblastic Tumor[J];Chinese Journal of Clinical Oncology;2001-08
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 Zhang Xiaowei,Zhang Lizhu, Zhou Xianmei,et al (Department of Obstetrics and Gynecology of the Third Hospital,Peking University,Beijing 100083);The relationship between the Y chromosome positive and the risk of developing persistent gestational trophoblastic disease of hydatidiform mole[J];Beijing Medical Journal;2002-02
2 NI Ya-li, LIU Zhen (The Hospital of Women and Children Health Care of Gansu Province, Lanzhou 730050, China);Expression and Its Clinical Significance of P_(53) in Pregnancy Trophoblast Tumor[J];Heilongjiang Medical Journal;2002-01
3 Yang Xingsheng,Zhang Zhenguo,Zhang Youzhong,et al.The Affliated Hospital of Shandong Medical University,250012;The predicting evaluation of c Ha ras,c erbB 2,p53 and nm23 gene products in the malignant transformation of hydatidiform mole.[J];CURRENT ADVANCES IN OBSTETRICS AND GYNECOLOGY;1998-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved