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《Acta Acadimae Qingdao Umvesitatis》 2004-04
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DETECTION OF BLOOD BIOCHEMICAL INDEXES IN FRACTURE TREATED WITH ZHUANG-GU-YE

GUO Shen-bo,YANG Zhi-hong,WANG Shou-biao,et al (Department of Pharmacology, Qingdao University Medical College,Qingdao 266021,China)  
Objective To explore the effects and mechanisms of Zhuang-gu-ye(ZGY) in the promotion of fracture hea- ling. Methods Eighty New Zealand rabbits, which had been made into fracture models, were randomly divided into four groups: large-dose(1 635 mg/kg); small-dose (327 mg/kg); Jie-gu-pian(224 mg/kg); and normal saline groups. After 9, 17, 30 and 42 days of treatment, the content of calcium and phosphorus and the activity of alkaline phosphatase (ALP) in the blood were measured. Results The concentration of calcium in the serum of the rabbits in the ZGY groups were obviously higher than that of the other groups at the 17th day ( F=13.11;q=5.61,5.26;P 0.05), while the concentration of phosphorus in the ZGY groups were obviously lower than that of the control groups at the 17th day( F=15.61;q=6.61,7.24;P 0.05). Conclusion Zhuang-gu-ye can promote the healing of fracture.
【CateGory Index】: R446.1
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