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《Acta Acadimae Qingdao Umvesitatis》 2005-02
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EFFECTS OF RUDITAPES PHILIPPINARUM ON THE PREVENTION AND TREATMENT OF ATHEROSCLEROSIS IN RABBITS

XING Cheng-ming,SHANG Yan-chang,YUAN Xiao-ling, et al (Department of Neurology,Tongji Hospital, Tongji Medical School of Huazhong University of Science and Technology,Wuhan 430030, China)  
Objective To observe the effect of Ruditapes Philippinarum on the development and regression of atherosclerosis in rabbits. Methods The experiment was carried out in two stages. In the first stage, 60 rabbits were randomly divided into four groups. Rabbits of group A_1 , B_1, C_1 ,and D_1 were given low fat diet, low fat and Ruditapes Philippinarum diet, high fat and Ruditapes Philippinarum diet, and high fat diet, respectively, for eight weeks. All the rabbits were then killed. In the second stage, another 80 rabbits were randomly divided into four groups. Rabbits of group A_2 and D_2 were given low fat diet and high fat diet, respectively, for 14 weeks. Those of group B_2 and C_2 received high fat diet for six weeks, and then a low fat diet with and without Ruditapes Philippinarum for eight weeks, respectively. Half of the rabbits of each group were killed at the end of the sixth week, and the others at the end of the 14th week. Serum total cholesterol(TC),triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C) and LDL-C/HDL-C were detected for all the rabbits every two weeks. Morphologic atherosclerosis of the ascending aorta was observed with light microscope and electro microscope. The intima-media thickness ratio (IMT) was measured. Results In the first stage, the serological and pathological indices of group B_1 did not change significantly as compared with those of A_1(P0.05). The plasma TC and TG levels and LDL-C/HDL-C ratio of group C_1 decreased significantly and HDL-C level increased, compared with those of group D_1 (F=2.89-3.95,q=4.02-4.39,P0.05). IMT decreased significantly (F=2.95,q=3.96,P0.05). Atherosclerosis improved pathologically. In the second stage, at the end of the sixth week, aorta IMT of group B_2, C_2 and D_2 was higher than that of group A_2 (F=2.89,q=3.85-4.21,P0.05). At the end of the 14th week, serum HDL-C of group B_2 was higher than that of group C_2 (F=3.08,q=3.96,P0.05), and aorta IMT of groups B_2 and C_2 was higher than that of group A_2 (F=2.75;q=3.88,4.42;P0.05),but lower than that of group D_2 ((q=)3.95,4.19;P0.05). Conclusion Ruditapes Philippinarum may decrease serum lipid and slow the progress of atherosclerosis. It can decrease the concentration of HDL-C thus plays an auxo-action for regression of atherosclerosis.
【CateGory Index】: R543.3
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