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《Acta Academiae Medicinae Qingdao Universitatis》 2006-03
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EFFECT OF RADIX ASTRAGALI AND RHUBARB ON GASTRIC INTRAMUCOSAL pH OF RABBITS WITH ACUTE LUNG INJURY INDUCED BY ENDOTOXIN

LI YU,LI SHU-HONG,ZHANG LIN, et al(Department of Anesthesia,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China)  
ObjectiveTo investigate the effect of radix astragali and rhubarb on the changes of gastric intramucosal pH of rabbits with acute lung injury induced by endotoxin.MethodsTwenty-four male New Zealand rabbits were evenly divided into four groups at random: group Ⅰ received only normal saline;group Ⅱ received radix astragali(8 g/kg);group Ⅲ received rhubarb(20 g/kg,);group Ⅳ received radix astragali(8 g/kg) combined with rhubarb(20 g/kg).Acute lung injury(ALI) was considered when level of PaO_2/FiO_2 was bellow 40 kPa.Gastric intramucosal carbondioxide was determined by gastric tonometry and HCO~-_3 by blood gas analysis at the onset of ALI,1 h,2 h,3 h,4 h,5 h and 6 h after ALI,respectively.Then,gastric intramucosal pH(pHi) was calculated via Henderson-Hasselbalch formula.ResultspHi in group Ⅱ and group Ⅲ were significantly higher than that in group Ⅰ at 6 h after ALI(F=6.15,q=5.83,P0.01;q=3.95,P0.05).ConclusionRhubarb can increase gastric intramucosal PHi,while Radix astragali alone can not change gastric intramucosal pHi.
【CateGory Index】: R285
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