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《Acta Academiae Medicinae Qingdao Universitatis》 2007-01
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LIU YUN-LING,YANG ZHONG-SI,CONG YU-ZI,et al(Department of Diagnostics,Wendeng No.2 People Hospital,Wendeng 264400,China)  
ObjectiveTo explore the changes of plasma vascular endothelial growth factor(VEGF) and von Willebrand factor(VWF) in patients with diabetic retinopathy(DR) and their significance.MethodsBy using ELISA,the changes of plasma VEGF and VWF were detected in 58 DR patients,of whom,non-proliferative DR(NPDR),28 cases;proliferative DR(PDR),30.The results were compare with 54 non-diabetic retinopathy (NDR) patients,and 49 healthy ones served as controls.Results The plasma VEGF and VWF were higher in the diabetic than those in the controls(t=27.09,28.85;P0.001).The VEGF and VWF were higher in DR patients than those in NDR(t=10.35,16.02;P0.001).The VEGF and VWF were higher in patients with PDR than those in NPDR(t=6.74,7.01;P0.001).There were positive correlation between VEGF and VWF in NPDR and PDR(r=0.560,0.629;P0.001).ConclusionThe changes of VEGF and VWF involve in the occurrence and development of DR,which are responsible for the seriousness of DR.
【CateGory Index】: R774.1
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