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《Acta Academiae Medicinae Qingdao Universitatis》 2007-03
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PROTECTIVE EFFECTS OF OYSTER GLYCOSAMINOGLYCAN ON THE INJURY OF VASCULAR ENDOTHELIAL CELLS INDUCED BY HYDROGEN PEROXIDE

WANG HAI-TAO,LIU SAI,SUN FU-SHENG(Department of Pharmacology,Qingdao University Medical College,Qingdao 266071,China)  
ObjectiveTo assess the protective effect of oyster glycosaminoglycan(O-GAG) on the injury of vascular endothelial cells(VECs) induced by hydrogen peroxide and its corresponding mechanism.MethodsThe endothelial cell strain from human umbilical vein was cultured and a model of VECs injured by hydrogen peroxide(H2O2) was established.This study was conducted as follows: normal control group,O-GAG control group(O-GAG 100,200,and 400 mg/L),H2O2-injury group(H2O2 50 mg/L),heparin group(heparin 200 mg/L,H2O2 50 mg/L) and O-GAG protective group(O-GAG 10,50,100,200,400,and 800 mg/L,H2O2 50 mg/L).Influence of O-GAG on proliferate activity of VECs was tested by means of MTT assay and levels of SOD were tested by xanthine oxidase.ResultsCompared with the normal control group,the proliferate activity of VECs of O-GAG control group was significantly increased(q=3.40,P0.05),while the proliferate activity of VECs and the levels of SOD of H2O2-injury group were markedly decreased(F=137.23,135.40;q=5.26,5.34;P0.01).Compared with O-GAG control group,the proliferate activity of VECs and levels of SOD of the O-GAG protective group were more significantly increased(q=3.40-5.11;P0.05,0.01).ConclusionO-GAG can protect the VECs from H2O2-induced injury,and the possible mechanism may refer to the increasing of SOD activity in the injured VECs.
【CateGory Index】: R285
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