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《Acta Academiae Medicinae Qingdao Universitatis》 2008-05
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A COMPARISON OF TWO METHODS IN MAKING ISCHEMIA-REPERFUSION MODEL OF MIDDLE CEREBRAL ARTERY IN RATS

LI JIAN-YUAN,ZHANG YA-ZHUO,YAO WEI-CHENG,et al(Department of Neurosurgery,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);  
Objective To make a transient middle cerebral artery occlusion model in rats,and to compare the methods of occlusion of common carotid artery and LONGA's technique. Methods The cerebral artery occlusion was obtained via blockage of either common carotid artery(CCA) or external carotid artery(modified LONGA's group).After two hours of artery occlusion and 24 hours of reperfusion,the rats were evaluated by LONGA's score standard.The volume of cerebral infarction was estimated by TTC staining.The number of apoptotic cells was detected by flow cytometry after seven days of occlusion. Results The neurological behavior scorings in modified LONGA's group and CCA group were 2.30±0.82 and 1.00±0.63,respectively(t=6.886,P0.05).The infarction volume between the two groups was significantly different(t=3.96-4.45,P0.05).The number of apoptotic cells was significantly different between the two groups(F=348.46,q=22.89,P0.05). Conclusion Compared with the CCA occlusion group,the neurological behavior scoring of modified LONGA's group was higher,the infarction volume was larger,the number of apoptotic cells was greater,and the stability was better.
【Fund】: 国家自然科学基金资助项目(30471766)
【CateGory Index】: R-332
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