Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Qingdao Universitatis》 2009-03
Add to Favorite Get Latest Update

IMPACT OF EXOGENOUS ALBUMIN ON C-REACTIVE PROTEIN AND PROCALCITONIN IN ARDS MICE

CHEN WEN-JING,QU YAN,HU DAN (Intensive Care Unit,Eastern Hospital of the Affiliated Qingdao Municipal Hospital of QingdaoUniversity Medical College,Qingdao 266000,China)  
Objective To investigate the effects of exogenous albumin on C-reactive protein(CRP) and procalcitonin(PCT) and the lung wet /dry(W/D) weight in mice with acute respiratory distress syndrome(ARDS).Methods This study consisted of 108 Kunming mice,which were randomized to two groups:normal control,12 mice,15 mg/kg of normal saline and vulnerated groups(96 mice,15 mg/kg of Endotoxin(LPS) to prepare ARDS models,both normal saline and LPS were in injected peritoneally.Treatment groups were divided into low-concentration-albumin(LCA) group(0.5 g/L of human serum albumin10 μL/g body mass),high-concentration-albumin(HCA) group(50.0 g/L of human serum albumin 10 μL/g body mass),and hydroxyethyl-starch(HS) group(60.0 g/L hydroxyethyl starch 10 μL/g body mass),the medicines were given through vena caudalis in the three groups.Blood samples were collected at 4 h after injection by breaking the neck in normal control,and at after4 h,8 h,16 h,and 24 h in vulnerated group(six mice per each time).Serum CRP and PCT were determined by ELASA,and lungs were detected for wet /dry weight.Results PCT increased with the extension of the time within 24 h,the differences were significant(H=17.97-21.60,q=4.08-6.88,P0.01).Compared with the untreated group,that of treated groups decreased at8 h,16 h,and 24 h(H=26.43-27.44,q=4.08-6.27,P0.01).No difference was found between HCA group and HS group(P0.05).Compared with the untreated group,the PCT in LCA group declined(t=23.37,28.32;H=15.16,19.55;q=4.08,4.58;P0.01);the difference of CPR between HCA group and HS group at 24 h was not significant(P0.05) W/D of the lungs in vulnerated group reached the top at 8 h and somewhat lowered at 16 h then recovered slightly at 24 h,the difference was significant as compared with the control(H=23.15-24.70,q=4.28-6.87,P0.01).Conclusion 50.0 g/L albumin can reduce lung wet /dry weight in early stage of ARDS,lower CRP and PCT,relieve inflammation and conduce to early treatment of ARDS.
【Fund】: 青岛市科技局科研基金资助项目(06-2-2-NSH)
【CateGory Index】: R563.8
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved