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《Acta Academiae Medicinae Qingdao Universitatis》 2009-05
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PROTECTIVE EFFECT OF β-CAROTENE ON RAT WITH ACUTE RADIATION DAMAGE

WANG JUAN-JUAN,MA AI-GUO,HAN LEI,et al(The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China)  
Objective To study the protection of β-carotene(β-C) on rat with acute radiation damage. Methods Forty female SD rats were randomized to four groups: normal control group(A),positive control groups(B),5 mg/(kg·d) β-C group(C) and 10 mg/(kg·d) β-C group(D).Before radiation,5 mg/(kg·d) of β-C was given to rats in group C,10 mg/(kg·d) of β-C to those in group D,and same volume of peanut oil was given to those in groups A and B.The intragastric administration lasted for 14 days.On 14th day,a single abdominal radiation of 9 Gy was offered to all the rats,except those in group A.The rats were sacrificed four days later,plasma superoxide dismutases(SOD),malondialdehyde(MDA),and glutathion peroxidase(GSH-PX) were detected and damage of DNA was checked using single cell gel electrophoresis technique. Results Compared with group B,the contents of MDA in groups C and D were significantly lower(F=5.23;q=4.20,2.80;P0.05);the activity of GSH-PX in group D was higher than that of group B(F=3.70;q=5.11;P0.05).The damage of DNA in group B was the most severe compared with the other three groups(F=105.06;q=19.85-21.53;P0.05). Conclusion Supplement of a certain dose of β-C will have a better protection on lipid peroxidation and oxidative damage of DNA induced by radiation injury of the abdomen.
【CateGory Index】: R818.71
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【Citations】
Chinese Journal Full-text Database 5 Hits
1 Ma Ai guo, Zang Jin lin, Song Feng rong, Zhang Ri jin (Institute of Human Nutrition, Medical College of Qingdao University, Qingdao 266021, China);COMPARISON RESEARCH OF SCGE, SCE AND CHROMOSOME ABERRATION FOR DETERMINING DNA DAMAGE[J];Carcinogenesis,Teratogenesis and Mutagenesis;2001-03
2 LI Yi,lan, QIAO Shan,shan, ZHOU Lei, et al. Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China;The Assist Protection by Beta,Carotene Against Gamma Radiation[J];Journal of Environment and Health;2004-05
3 BI Ying-hui,HAN Jun-qing,SHENG Wei,LI Zhao-pei,HU Ping-ping,SHEN Bin(Tumor Research and Treatment Center,Shandong Provincial Hospital,Shandong University,Jinan 250021,Shandong,China);Actovegin restores the digestive tract in rats with acute radiation enteritis[J];Journal of Shandong University(Health Sciences);2007-03
4 ZHOU XIAO-BIN,JI XIN-QIANG,XU LI(Department of Preventive Medicine,Qingdao University Medical College,Qingdao 266021,China);THE COMPOSITION AND APPLICATION OF PPMS 1.5 MEDICAL STATISTICAL SOFTWARE[J];Medical Journal of Qilu;2009-01
5 DONG Guanglong, LIU Xiaoling, WANG Weizhong. Department of Gastroenterological Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032;The model of gut mucosa barrier injury by abdominal radiation in rats[J];CHINESE JOURNAL OF CHINICAL NUTRITION;2000-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SUN Yong-ye,MA Ai-guo,JIA Yi-na,ZHANG Xiu-zhen(Institute of Nutrition ,Medical College of Qingdao University,Qingdao 266021,China);The Effect of Gynostemma Pentaphyllum Extract on DNA Damage of Aging Rats[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-05
2 LIANG Yun et al(State Key Laboratory of Food Science and Technology,School of Food Science and Technology,Jiangnan University,Wuxi,Jiangsu 214112);Comparative Study on the Abilities of Scavenging Free Radical of Some Natural Antioxidants[J];Journal of Anhui Agricultural Sciences;2008-06
3 ZHAO Yan-jing et al (Jiangsu Key Laboratory of Marine Biotechnology,Huaihai Institute of Technology,Lianyungang,Jiangsu 222005);Study on the Antioxidation of Water Extract from Three Species of Razor Shell[J];Journal of Anhui Agricultural Sciences;2008-31
4 Zhao Ying, Wang Zhi-qiang, Yang Zhi-ping, Wang Wei, Huang Xiao-mu (Anhui Center for Disease Control and Prevention ,Hefei,Anhui,230061,China);Initial Observation on DNA Trauma of Fish Red Blood Cell Caused by organic distill from Chaohu Lake[J];Anhui Journal of Preventive Medicine;2003-03
5 XUE MEI-LAN,ZHANG XIU-ZHEN,MA AI-GUO,et al (Department of Biochemistry and Molecular Biology,Qingdao University Medical College,Qingdao 266021,China);THE EFFECT OF HIGH-DOSE VITAMIN C ON PERIPHERAL BLOOD CELL ACTIVITY[J];Acta Academiae Medicinae Qingdao Universitatis;2009-01
6 ZHANG XIAO-HONG,CHEN XI,JIANG ZHENG-YAO (Department of Physiology,Qingdao University Medical College,Qingdao 266071,China);EFFECTS OF α-MSH ON GASTRIC DISTENSION SENSITIVE NEURONS IN RAT DORSAL VAGAL COMPLEX[J];Acta Academiae Medicinae Qingdao Universitatis;2009-03
7 LIU ZHU-ZHEN,YANG JIE,WANG HONG-YI,et al (Department of Hematology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);THE EFFECTS OF THALIDOMIDE-COMBINATION CHEMOTHERAPY ON CYTOKINE IN PATIENTS WITH MULTIPLE MYELOMA[J];Acta Academiae Medicinae Qingdao Universitatis;2009-03
8 L SEN-SEN,WU XIU-YING,HAN LIN,et al (Department of Endocrinology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);POLYMORPHISMS IN 3'-UNTRANSLATED REGION OF URATE TRANSPORTOR 1 RELATED TO HYPERURICEMIA[J];Acta Academiae Medicinae Qingdao Universitatis;2009-03
9 LI KUN,GE YIN-LIN (Department of Biochemistry and Molecular Biology,Qingdao University Medical College,Qingdao 266021,China);EFFECT OF DOWN-REGULATION VEGF-C GENE ON MULTIPLICATION AND APOPTOSIS OF BREAST CANCER CELLS[J];Acta Academiae Medicinae Qingdao Universitatis;2009-03
10 CHEN WEN-JING,QU YAN,HU DAN (Intensive Care Unit,Eastern Hospital of the Affiliated Qingdao Municipal Hospital of QingdaoUniversity Medical College,Qingdao 266000,China);IMPACT OF EXOGENOUS ALBUMIN ON C-REACTIVE PROTEIN AND PROCALCITONIN IN ARDS MICE[J];Acta Academiae Medicinae Qingdao Universitatis;2009-03
China Proceedings of conference Full-text Database 2 Hits
1 SUN ZHONGQING,ZHONG CHUNMEI,WANG ZHIXU,et al (Institute of Human Nutrition,Qingdao University Medical School,Qingdao 266021,China);AN INVESTIGATION ON CHILD REARING PRACTICES IN BEIJING TIANJING AND QINGDAO[A];[C];2010
2 ZHANG Wenhua,YAO Qiang,ZHU Siwei,QIN Yukun,JIA Peijie. Department of Oncology,Tianjin Union Medicine Centre,Tianjin,300121,China;The influence of Jiawei Tongxieyaofang Decoction on rat with acute radiation enteritis[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Lu Wenqiao(Affiliated Hospital of Shandong TCM University, Shandong 250011 China);Actovegin injection external application to treat 33 patients with bed-sore[J];;2005-08
2 Yang Lin, Zhang Yueming , Xu Zhenrong , Zhengyupei , Ding Hong  (Health and Epidemic Prevention Station of Xinjiang Military Region, Wulumuqi 830011);The Experimental Study of the Antitumor Effects of β carotene on the Growth of Human Cancer Cells[J];ACTA NUTRIMENTA SINICA;1999-04
3 SHEN Li, WANG Shen, XIE Fang, ZHU Xu ming, WEI Pi jing (School of Basic Medicine, Shanghai Second Medical University, Shanghai 200025,China);THE PROTECTIVE EFFECT OF β-CAROTENE IN ANOXIA-INJURED CARDIOMYOCYTES[J];Acta Nutrimenta Sinica;2001-02
4 SHEN Hui-qin, GAO Ying (No.2 Hospital of Shanxi Medical University, Taiyuan 03001, China);EFFECTS OF β-CAROTENE ON THE STABILITY OF RBC-MEMBRANE STRUCTURE IN RATS[J];Acta Nutrimenta Sinica;2001-04
5 Zhou Xinwen,Zhang Yueming,Zhen Yupei,Cui Qingping(Department of Preventive Medicine Xingjiang Medical College,Urumqi 830054);TX THE EXPERIMENTAL STUDY ON THE ANTITUMOR EFFECTS OF BETACAROTENE AND SODIUM SELENITE IN VITRO[J];ACTA NUTRIMENTA SINICA;1998-01
6 PAN Tian hong,MIAO Ling,JIN Hui fang,et al. (Department of Neurology,Renji Hospital Affiliated to Shanghai Second Medical University,Shanghai 200001 China);Analysis the Correlation between the β-carotene and LDL in serum of stroke patients[J];JOURNAL OF APOPLEXY AND NERVDUS DISEASES;2000-02
7 ZHANG Jing,ZHANG Jun,LIU Yi min,et al.Department of Preventive Medicine,Medical College,Tongji University(Shanghai 200070,China);Effects of β-Carotene on Changes of Lipid Peroxidation and Antioxidant Enzyme of Alveolar Macrophage Induced by Ni_2O_3[J];China Public Health;2002-08
8 DONG Guanglong, LIU Xiaoling, WANG Weizhong. Department of Gastroenterological Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032;The model of gut mucosa barrier injury by abdominal radiation in rats[J];CHINESE JOURNAL OF CHINICAL NUTRITION;2000-03
9 LIN Hong,WU Wei,ZHANG Kunhe,et al.The First Affiliated Hospital,Jiangxi Medical College,Nanchang 330006,China\;;The prophylactic and protective effects of egg yolk immunoglobulin against Escherichia coli on radiation-induced enteritis in rats[J];Chinese Journal of Radiation Mediation and Protection;2002-02
10 DING Xiao-fan,LI De-xing,ZHAO Lin. Department of Oncology,Jiangmen Central Hospital of Guangdong Province,Jiangmen 529000,China ;;Therapeutic efficacy of fever-reducing and invigorating Chinese medicine in the treatment of patients with acute radiation enteritis and its effects on nitric oxide level and morphometrics in intestinal mucosa with radiation-induced enteritis in r[J];Chinese Journal of Radiation Mediation and Protection;2004-01
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