Full-Text Search：
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Qingdao Universitatis》 2010-06
Add to Favorite Get Latest Update

THE PROTECTION OF TOTAL FLAVONOID OF HERBA EPIMEDII AGAINST MPP~+-INDUCED TOXICITY IN MES23.5 CELLS

XU AI-LI,ZHANG YANG,ZHOU LI-PING,et al(State Key Disciplines: Physiology(in incubation),Faculty of Medicine,Qingdao University,Qingdao 266071,China)  
Objective To study the protection of total flavonoid of Herba Epimedii(TFHE) against 1-methyl-4-phenylpyridinium(MPP+)-induced neurotoxicity. Methods MES23.5 cells were cultured as routine and pretreated with TFHE for24 h,and then co-treated with MPP+ and TFHE for 24 h.The survival of the cells was observed by MTT method.The real time RT-PCR was used to detect the gene expressions of bcl-2 and bax. Results MPP+ damaged MES23.5 cells as a dose-dependent manner(F=18.38,P0.001).Pretreatment with TFHE could obviously against toxic action of MPP+(F=44.36,P0.001).MPP+ had no significant effect on bcl-2 gene expression,but increased the gene expression of bax(F=10.92,P0.05).Pretreatment of TFHE increased the bcl-2 gene expression(F=15.76,P0.01) and reversed the increase of bax gene expression(F=10.92,P0.05). Conclusion Total flavonoid of Herba Epimedii has an antagonistic action on MES23.5 cells damage induced by MPP+,of which,the mechanism may be related to its anti-apoptosis effects.
【Key Words】： total flavonoid of Herba Epimedii 1-methyl-4-phenylpyridinium apoptosis MES23.5 cells
【Fund】： 国家自然科学基金资助项目(30971004);; 山东省自然科学基金资助项目(Y2007D49)
【CateGory Index】： R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 ZHOU LI-PING,GE KE-LI,CHEN WEN-FANG(State Key Disciplines: Physiology(in incubation),Faculty of Medicine,Qingdao University,Qingdao 266071,China);PROTECTION OF GINSENOSIDE Rg1 AGAINST-AMYLOID PEPTIDE-INDUCED NEUROTOXICITY IN MICE HIPPOCAMPAL NEURONS[J];Acta Academiae Medicinae Qingdao Universitatis;2011-03
2 WANG WEN-JIE,SONG NING,XIE JUN-XIA,WANG JUN (State Key Disciplines: Physiology,Qingdao University Medical College,Qingdao 266071,China);THE EFFECT OF PMA ON THE ACTIVATION OF IRON REGULATORY PROTEIN-1 IN MES 23.5 CELLS[J];Acta Academiae Medicinae Qingdao Universitatis;2011-05
3 WU Lin,XUE Dandan,YANG Jing,YANG Bowen,CHEN Wenfang (State Key Disciplines: Physiology(in incubation),Faculty of Medicine,Qingdao University,Qingdao 266071,China);THE PROTECTIVE EFFECT OF TOTAL FLAVONOID OF HERBA EPIMEDII ON DOPAMINERGIC NEURONS IN MOUSE MODEL OF PARKINSON'S DISEASE[J];Acta Academiae Medicinae Qingdao Universitatis;2013-01
【Citations】
Chinese Journal Full-text Database 3 Hits
1 XU Haowen, LIU Guangyi, GUO Yunliang \ Institute of Cerebrovascular Diseases, Qingdao University Medical College, Qingdao 266003\; [;THE EXPRESSION OF Bcl-2 AND P53 IN ENDOTHELIAL CELLS AFTER FOCAL CEREBRAL ISCHEMIA/REPERFUSION IN RATS[J];Acta Acadimae Medicinae Qingdao;2001-01
2 WANG MING-BO,CHEN WEN-FANG,XIE JUN-XIA(Department of Physiology,Faculty of Medicine,Qingdao University,Qingdao 266071,China);;THE PROTECTIVE EFFECT OF GINSENOSIDE Rg1 AGAINST 6-OHDA-INDUCED NEUROTOXICITY IN MES23.5 CELLS[J];Acta Academiae Medicinae Qingdao Universitatis;2008-05
3 XIAO Xing-feng, WANG Zhi-qiang, LOU Yi-jia(College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China);Immunoregulation of icariin combined with Panax notoginseng saponins in mice[J];Chinese Traditional and Herbal Drugs;2006-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 CHEN Yan, GUO Yunliang \ Institute of Cerebrovascular Diseases, Qingdao University Medical College, Qingdao 266003\;;THE EXPRESSION OF bcl-2 AND p53 mRNA IN NEURONS AFTER REPERFUSION FOR CEREBRAL ISCHEMIA IN RATS[J];Acta Acadimae Medicinae Qingdao;2002-02
2 WANG MING-BO,CHEN WEN-FANG,XIE JUN-XIA(Department of Physiology,Faculty of Medicine,Qingdao University,Qingdao 266071,China);;THE PROTECTIVE EFFECT OF GINSENOSIDE Rg1 AGAINST 6-OHDA-INDUCED NEUROTOXICITY IN MES23.5 CELLS[J];Acta Academiae Medicinae Qingdao Universitatis;2008-05
3 GE KE-LI,CHEN WEN-FANG(State Key Discipline: Physiology(in incubatin),Faculty of Medicine,Qingdao University Medical College,Qingdao 266071,China);GINSENOSIDE Rg1 PROTECTS AGAINST 6-OHDA-INDUCED TOXICITY VIA THE ACTIVATION OF PI3K/Akt SIGNALING PATHWAY[J];Acta Academiae Medicinae Qingdao Universitatis;2009-05
4 ZHOU LI-PING,GE KE-LI,CHEN WEN-FANG(State Key Disciplines: Physiology(in incubation),Faculty of Medicine,Qingdao University,Qingdao 266071,China);PROTECTION OF GINSENOSIDE Rg1 AGAINST-AMYLOID PEPTIDE-INDUCED NEUROTOXICITY IN MICE HIPPOCAMPAL NEURONS[J];Acta Academiae Medicinae Qingdao Universitatis;2011-03
5 MENG Ning,KONG Kai,LI Shi-weng(School of Chemical and Biological Engineering,Lanzhou Jiaotong University,Lanzhou 730070,China);Advances in Studies on Chemical Constituents and Pharmaceutical Activities in Species of Epimedium[J];Acta Botanica Boreali-Occidentalia Sinica;2010-05
6 GUO Ai-wei,ZHU Jing,CHEN Fen-fen,ZHOU Jie-long(College of Conservation Biology,Southwest Forestry College,Kunming,Yunnan,650224,China);Progress on Immune Function of Chinese Herbal Medicines[J];Progress in Veterinary Medicine;2008-11
7 WU Lin,XUE Dandan,YANG Jing,YANG Bowen,CHEN Wenfang (State Key Disciplines: Physiology(in incubation),Faculty of Medicine,Qingdao University,Qingdao 266071,China);THE PROTECTIVE EFFECT OF TOTAL FLAVONOID OF HERBA EPIMEDII ON DOPAMINERGIC NEURONS IN MOUSE MODEL OF PARKINSON'S DISEASE[J];Acta Academiae Medicinae Qingdao Universitatis;2013-01
8 LI Fengxiao,WANG Lei,GAO Shengmei,SHI Yanqian(Department of Pharmacology,Qingdao University Medical College,Qingdao 266021,China);THE PROTECTION OF TAURINE AGAINST Aβ_(1-40)-INDUCED TOXICITY IN HUMAN NEUROBLASTOMA CELL LINE SH-SY5Y[J];Acta Academiae Medicinae Qingdao Universitatis;2013-04
9 JIA Liang-liang, YUAN Ding, WANG Hong-wu, HE Yu-min, ZHANG Chang-cheng (Medical College of China Three Gorges University, Yichang 443002, China);The Pharmacological Research Advance of Icariin[J];Progress in Modern Biomedicine;2010-20
10 LI Li,WANG Xue-mei(Department of Integrated Chinese and Western Medicine,First Hospital,Peking University,Beijing 100034,China);Progress of pharmacological research on icariin[J];China Journal of Chinese Materia Medica;2008-23
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 HOU Li-li et al(Biological and Agricultural Engineering College,Jilin University,Changchun,Jiling 130022);Study on Antioxidant Activity of Epimedium Extract[J];Journal of Anhui Agricultural Sciences;2011-03
2 ZHAO Zhi-ming,CAI Jia-yu,JIAO Dong-dong,ZHAO Ling-jie,CAI Hui(Department of Integrated Traditional Chinese and Western Medicine,Nanjing General Hospital of Nanjing Military Command,Chinese PLA,Jiangsu Nanjing 210002,China);Effect of Total Flavonoids of Epimedium on Plasma Levels of TNF-α in Rats with Congestive Heart Failure[J];Journal of Anhui Traditional Chinese Medical College;2010-04
3 WANG MING-BO,CHEN WEN-FANG,XIE JUN-XIA(Department of Physiology,Faculty of Medicine,Qingdao University,Qingdao 266071,China);;THE PROTECTIVE EFFECT OF GINSENOSIDE Rg1 AGAINST 6-OHDA-INDUCED NEUROTOXICITY IN MES23.5 CELLS[J];Acta Academiae Medicinae Qingdao Universitatis;2008-05
4 DU TING-TING,SONG NING,XIE JUN-XIA,et al (State Key Discipline: Physiology(in Incubation),Department of Physiology,Qingdao University,Qingdao 266071,China);NEUROPROTECTIVE EFFECT OF ROSMARINIC ACID ON 1-METHYL-4-PHENYLPYRIDINIUM INDUCED CYTOTOXICITY OF THE MES 23.5 CELLS[J];Acta Academiae Medicinae Qingdao Universitatis;2010-03
5 LIU Hao-ran1,LIU Ying-lin1, PENG Xiang-Dong2, QI Min-you3,WANG Yu-hong4, LI Ya4, LI Yan-lai1 (1 College of Chemical and Chemistry Engineering, Hu’nan University, Changsha 410082,China; 2 The 3rd Hospital of Xiang-ya Medical College, Southern Central University,Changsha 410078,China; 3 College of Pharmacy, Zhe jiang University of Industry, Hangzhou 310014,China; 4 The laboratory of TCM pharmacology and screening for TCM active fractions, Hu'nan University of TCM, Changsha 410007, China);Effects of total flavones of Epimedium brevicornu Maxim on testis diseases in D-galactose-induced aging rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-05
6 ZHAI Yuan-kun1,WANG Ming-gang1,LI Zhi-zhong1,ZHANG Na2 (1College of Life Science and Engineering,Lanzhou University of Technology,Lanzhou 730050,China;2Laboratory of Centers for Disease Control and Prevention,Lanzhou Command,Lanzhou 730020,China);Effects of the serum of rats administered icariin on the proliferation and osteogenic differentiation of rBMSCs in vitro[J];China Journal of Traditional Chinese Medicine and Pharmacy;2012-02
7 FU Li-bo1,2,XU Hai-yan2,LIU Feng-lian3,YANG Yan-long1,YANG Yan-ping2(1.Basic Medical College,Jinlin University,Changchun 130021,China;2.College of Life Sciences,Changchun Teachers College,Changchun 130032,China;3.Experiment and Education Technology Center,Linyi Teachers College,Linyi 276005,China);Effects of epimedium on blood pressure in normal and stress-induced rats[J];Journal of Northeast Normal University(Natural Science Edition);2008-01
8 Li Shutong; Li Tiejun; Zheng Qinyue; Wang Hongbin (Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai,200433);Effects of icariine on lymphocyte proliferation and production of colony stimulating factor-like activity from mice splenocytes in vitro[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1995-04
9 ZENG Jing,HUANG Xian hua,YE He yang,LIA Fei,YANG Jing ge,ZHU Zun ping (Department of Pharmacology, Gan Nan Medical College, Ganzhou jianxi 341000);The Effect of Herba Epimedium Water Extract on Anti-hypoxia[J];Journal of Gannan Medical College;2002-04
10 LI Liang-dong, ZENG Jing, HUANG Zhi-hua,et al (Department of Pharmacy, Gannan Medical college, Jiangxi Ganzhou 341000 );A study on the Analgesic Effect of Herba Epimedium Extract[J];Journal of Gannan Medical College;2004-01
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 WANG Hong-cai1,JIANG Yu-meng1,ZHAO Xue1,WANG Ning1,GAO Di2, GUAN Ming2,ZHANG Jing-yu1,YANG Zi-chao1(1.Department of Neurology,Fourth Affiliated Hospital,Harbin Medical University,Harbin 150001,China; 2.Department of Pharmaceutical Analysis,School of Pharmacy,Jilin University,Changchun 130021,China);Protective effect of ginsenoside Rb1 on hippocampal neuron injury after treated by Aβ-amyloid protein in rats[J];Journal of Jilin University(Medicine Edition);2012-03
2 HE Dao-tong,WANG Bing,CHEN Jun-ming(Sixth People's Hospital of Shanghai Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200233,China);Research Progress on Pharmacological Effects of Ginsenoside[J];Journal of Liaoning University of Traditional Chinese Medicine;2012-07
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 XU Haowen, LIU Guangyi, GUO Yunliang \ Institute of Cerebrovascular Diseases, Qingdao University Medical College, Qingdao 266003\; [;THE EXPRESSION OF Bcl-2 AND P53 IN ENDOTHELIAL CELLS AFTER FOCAL CEREBRAL ISCHEMIA/REPERFUSION IN RATS[J];Acta Acadimae Medicinae Qingdao;2001-01
2 LU WEN-JING,WANG GUI-ZHI(Department of Dermatology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);EFFECT OF CALCITONIN GENE-RELATED PEPTIDE ON PROLIFERATION AND APOPTOSIS OF HaCaT CELLS[J];Acta Academiae Medicinae Qingdao Universitatis;2008-02
3 XU Li1,LIU Li-xing1,CHEN Wen-fang1,XIE Jun-xia1,HUANG wen-xiu2 (1.Deparment of Physiology,Medical College of Qingdao University,Qingdao 266071;2.Department of Applied Biology and Chemical Technology,The Hong Kong Polytechnic University,Hong Kong SAR,China);THE PROTECTIVE EFFECT OF GINSENOSIDE RG1 ON DOPAMINERGIC NEURONS OF SUBSTANTIA IN THE OVARIECTOMIZED RAT MODEL OF PARKINSON'S DISEASE[J];Chinese Journal of Applied Physiology;2008-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved