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《ACTA ACADIMAE MEDICINAE QINGDAO》 1999-01
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CYTOCHEMICAL AND ULTRASTRUCTURAL STUDIES ON THE INFLUENCE OF KADSURENONE UPON THE IMPLANTATION OF MOUSE EMBRYOS

Yu Xiangmin,Wang Wenqing,Wu Cuijiao,] et al\ Department of Histology and Embryology, Qingdao Medical College, Qingdao 266021\;  
Objective \ To investigate the effect of Kadsurenone on the implantation of mouse embryos and to observe the cytochemical and ultra structural changes.\ Methods \ On the day 2 of pregnancy, Kadsurenone in different dosages was intrauterohornly injected into the mice. On the day 8 and day 10 of pregnancy, the expression of WGA and ConA receptors as well as ultrastructural changes in trophoblastic cells and decidual cells were observed.\ Results \ Cytochemical observations showed that the positive reaction of WGA and ConA receptors of trophoblastic cells weakened along with the increasing dosages of Kadsurenone, notablly with the WGA staining. Ultrastructurally, the cytoplasms of trophoplastic cells within the superficial area in the experimental groups became less dense, nuclei pyknosed; while in the deeper area, the lysosomes in the trophoblastic cells remarkablly increased in number, Even the myelinated bodies were found in these cells. In larger decidual cells, the lysosomes were also greatly increased accompanied by vacuolation of the cytoplasm and rupture of the nuclear membrane.\ Conclusions \ By means of decreasing the amount of glycoprotein in WGA and ConA receptors in trophoblastic cells, Kadsurenone can interfere with the intercellular adherence and attachment, destroy the enviroment where the embryos survived and developed and inhibit the process of implantation.
【Fund】: 山东省自然科学基金
【CateGory Index】: R965
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