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《Chinese Journal of Virology》 1992-04
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STUDIES ON ADJUVANT ACTIVITY AND SAFETY OF A NEW IMMUNOADJUVANT, ASDP/ASDE3, OF RECOMBINANT HEPATITIS B VACCINE

Liu Zhongxun Zuo Zenyan Lin Futian Yu Fong Xu Jin Song Kungai Liu HaiqunInst: tute of Medicinal Biotechnology, CAMS, Beijing  
A new immunoadjuvant, ASDP/ASDE3, tested with recombinant hepatitis B surface antigen ( HBsAg ) vaccine was reported. It is derived from the Chinese traditional tonic medicine, Angelica sinensis (Oliv. ) Diels by chemical extraction and purification.The immunoadjuvant activity of ASDP/ASDE3 is significantly higher than that of aluminium hydroxide gel used as a control in a number of parameters. The ED50 of anti-HBs conversion was 2-4 folds smaller than that of aluminium hydroxide. The anti-HBs titers were at least 20 folds higher.The acute toxicity ( LD50 ) of new immuno-adjuvamt in mouse by subcutaneous, intramuscular and intravenous injection are 2,000mg/ kg, 800mg/kg and 200mg/kg respectively.No marked pathological changes and tissue damages were observed after local administration of ASDP/ASDE3 by various routes.ASDP/ASDE3 did not induce type I allergic reaction in mice and guinea pigs.It can activate the lysosomyl enzymes ( acidic phosphatase, N-ace-tylamino-glucosidase ) and modulate the membrane enzymes ( alkaline phosphatase and alkaline phosphodiesterase ) of peritoneal macrophage of mice in vivo.ASDP/ASDE3 is a new adjuvant with high efficacy and low toxicity. Chinese traditional medicine may be a new approach to the further study and development of new immunoadjuvant.
【Fund】: 国家863高科技生物技术领域资助
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