Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Virology》 1992-04
Add to Favorite Get Latest Update


Liu Zhongxun Zuo Zenyan Lin Futian Yu Fong Xu Jin Song Kungai Liu HaiqunInst: tute of Medicinal Biotechnology, CAMS, Beijing  
A new immunoadjuvant, ASDP/ASDE3, tested with recombinant hepatitis B surface antigen ( HBsAg ) vaccine was reported. It is derived from the Chinese traditional tonic medicine, Angelica sinensis (Oliv. ) Diels by chemical extraction and purification.The immunoadjuvant activity of ASDP/ASDE3 is significantly higher than that of aluminium hydroxide gel used as a control in a number of parameters. The ED50 of anti-HBs conversion was 2-4 folds smaller than that of aluminium hydroxide. The anti-HBs titers were at least 20 folds higher.The acute toxicity ( LD50 ) of new immuno-adjuvamt in mouse by subcutaneous, intramuscular and intravenous injection are 2,000mg/ kg, 800mg/kg and 200mg/kg respectively.No marked pathological changes and tissue damages were observed after local administration of ASDP/ASDE3 by various routes.ASDP/ASDE3 did not induce type I allergic reaction in mice and guinea pigs.It can activate the lysosomyl enzymes ( acidic phosphatase, N-ace-tylamino-glucosidase ) and modulate the membrane enzymes ( alkaline phosphatase and alkaline phosphodiesterase ) of peritoneal macrophage of mice in vivo.ASDP/ASDE3 is a new adjuvant with high efficacy and low toxicity. Chinese traditional medicine may be a new approach to the further study and development of new immunoadjuvant.
【Fund】: 国家863高科技生物技术领域资助
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 5 Hits
1 ZHU Zheng 1 ,HU Yun-zhang 2 ,QIAN Zi-gang 1 ,1.Department of Pharmacy,Yunnan College of TCM,Kunming650200;2.Institute of Medical Biology,Chinese Academy of Medical Sciences,Kunming650118,China;Active components of some tonic Chinese herbs as novel human vaccine adjuvants[J];Letters in Biotechnology;2004-01
2 LIU Ji-yong1,WANG Ying-ping1,TIAN Li2(1.Institute ofSpecial Wild Economic Animals and Plants,CAAS.,Jilin 132109,China;2.Jilin Longtan Mountain Deer Industry CO.,Ltd.J,ilin 132000,China);Status of the Traditional Chinese Medicine Chemical Substance in Immunoenhancer Activity[J];Special Wild Economic Animal and Plant Research;2010-03
3 OU Yang-Jie 1, HU Yun-zhang 2, QIAN Zi-gang 1 (1.Department of Pharmacy, Yunnan College of TCM, Kunming 650200,China;2.Institute of Medicinal Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming 650118,China);Innune Polysaccharides of Traditional Chinese Medicine as Vaccine Adjuvant[J];Journal of Yunnan College of Traditional Chinese Medicine;2002-02
4 DENG Xiao-hong(Research Center of Medical Chemistry and Chemical Biology,Chongqing Technology and Business University,Chongqing 400067,China);Research progress in Chinese traditional immunopoteniators[J];Journal of Chongqing Technology and Business University(Natural Science Edition);2006-06
5 Shi Xiaohong, Song Gan, Hang Changshou, et al Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052;IMMUNE RESPONSE TO RECOMBINANT NUCLEOCAPSID PROTEIN AND GLYCOPROTEINS OF HANTAAN VIRUS IN EXPRIMENTAL ANIMALS[J];Chinese Journal of Microbiology and Immunology;1995-04
Chinese Journal Full-text Database 10 Hits
1 DUAN Xian-chun,WANG Yong-zhong,ZHOU An,JU Jing,XIA Lun-zhu(Department of Pharmacy,Anhui College of Traditional Chinese Medicine &Anhui Key Laboratory for Research and Development of Modern Chinese Medicine,Anhui Hefei 230038,China);Extraction,Isolation and Identification of Panaxynol from Panax Notoginseng[J];Journal of Anhui Traditional Chinese Medical College;2008-02
2 Wu Chuanmao Wu Zhouhe Wu Yesong (Biological engineering of Hu Bei Institute of technology 430068);Study on Antibacterial Activity of Ethanol Extract of Cinamomum camphora[J];AMINO ACIDS & BIOTIC RESOURCES;2000-02
3 HAN Yi, DAI Can, TANG Lu-ying (Collge of Life Seiences, Wuhan University, Wuhan 430072, China);A Preliminary Study of Virus-Inhibiting Effect of Volatile Oil from Artemsia argyi[J];Amino Acids & Biotic Resources;2005-02
4 GAO Li-juan,LIU Pu, ZHANG Wei,LIN Bing-chang (School of Chemical Engineering,Anshan University of Science and Technology,Anshan 114044,China);Study on conditions for hydrolyzing higher purified flavonoids[J];Journal of Anshan University of Science and Technology;2004-04
6 Zhao Jihong 1) Liang Yu 2) Yan dayu 2) (1)College of Basic Sci., North China Univ. of Tech., 100041, Beijing, China 2) Graduate School of Univ. of Sci. &Tech. of China, 100039, Beijing, China);Structure-Antioxidation Relationship of Flavonoid Antioxidants[J];Journal of North China University of Technology;2001-01
7 LIU Ying Fang WANG Wan Xian NIE Ran PENG Yu (College of Life Science, Hubei University, Wuhan 430062,China);The Effect of the Soaking Liquids of Cinnamomum camphora on Killing Oncomelania hupensis[J];Chinese Journal of Zoology;2004-03
8 Jj Dixin, Yan Jichang and Wei Yongdi;A study on the chemical constituents of steamed-ginseng-water[J];;1987-06
9 Liu Weihong,Gong Shouliang,Li Xinmin, Liu Shuzheng (Deparment of Radiation Biology);Radioprotective effect of Panaxatriol on immune organs in male rats[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1994-01
10 Liu Zhonghui,Wang Shuhe,Yang Guizhen(Department of Immunol ogy );Regulatory effects of ginsenoside on inhibition of immune function induced by extrogenous ACTH[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1995-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 WANG Yan et al (College of Animal Husbandry and Veterinary,Henan Agricultural University,Zhengzhou,Henan 450002);Effects of Interferon on Antibody Titer of Inactive ND Vaccine[J];Journal of Anhui Agricultural Sciences;2008-31
2 Wu Haiyan; Yao Chuzheng(Institute of Epidemiology & Microbilogy, Chinese Academy of Preventive Medicine, Beijing, 102206 )The role of immune niurine peritoneal macrophage (PMΦ) was studied in experimental infec-tion with Hemorrhagic Fever with Renal Synd;A PRELIMINARY STUDY ON THE ROLE OF IMMUNEMACROPHAGES AGAINST HEMORRHAGIC FEVER WITHRENAL SYNDROME VIRUS INFECTION IN MICE[J];Chinese Journal of Virology;1996-04
3 LI Guang-Yu, HUANG Chang-Xing, BAI Xue-Fan, PAN Lei, YANG Wei-Song Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China;Immunoprotection of Hantaan virus envelope glycoproteins G1 and G2 expressed in E.coli[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-07
4 ZHENG Xing-wen~1,GONG Min~2,ZENG Xian-guang~2,JIANG Chun-mei~2,ZENG Xiang-mei~2,ZHANG Ting~2 1.School of Chemistry and Pharmaceutical Engineering,Sichuan University of Science & Engineering,Zigong 643000; 2.School of Material and Chemical Engineering,Sichuan University of Science & Engineering, Zigong 643000;Inhibition of Extractives from Cinnamomum Camphor Leaves on Carbon Steel in H_2SO_4 Solution[J];Corrosion Science and Protection Technology;2012-01
5 BAI Yu,YANG Huan(Office of Evaluation V,Center for Drug Evaluation,State Food and Drug Administration,Beijing 100038,China);Considerations for clinical trials of new vaccines[J];The Chinese Journal of Clinical Pharmacology;2007-04
6 XIONG Qi-yan1,FAN Zhi-peng1,2,GAN Yuan1,KONG Meng1,FENG Zhi-xin1, LIU Mao-jun1,SHAO Guo-qing1(1.Key Laboratory of Animal Diseases Diagnostic and Immunology,Ministry of Agriculture,National Center for Engineering Research of Veterinary Bio-products,Institute of Veterinary Medicine,Jiangsu Academy of Agricultural Sciences, Nanjing 210014,China;2.Graduate College of Shanxi Agricultural University,Taigu 030801,China);Immune Study of a Intramuscular Injected Live Vaccine against Mycoplasma hyopneumoniae Enhanced by Different Adjuvants[J];China Animal Husbandry & Veterinary Medicine;2011-10
7 JIANG Wei-ming1,LI Yan2,WANG Shi-chang2,PAN Zhi-zhong1(1 Guangxi Fisheries Research Institute,Nanning 530022,China;2 College of Animal Sciences and Technology,Guangxi University,Nanning 530005,China);Effect of Sargassum polysaccharides on immune response to PRRS inactivated vaccines[J];Guangxi Agricultural Sciences;2009-10
8 LIANG Yan,HUANG Lian,CHANG Haiyan,CHEN Ze,FANG Fang~* (College of Life Sciences,Hunan Normal University,Changsha 410081,Hunan,China);Antibody Responses Induced by Inactivated New Influenza A Virus(H1N1)Vaccine with Ginseng Polysaccharide as an Adjuvant[J];Acta Laser Biology Sinica;2012-01
9 NI Jia-ning,L Ying-jun,BAO En-dong (Coll of Vet Med,Nanjing Agric Univ,Nanjing 210095,China);Effects of IFN-α and immune activities induced by Poly I∶C microcapsule in Newcastle disease virus infected broilers[J];Journal of Yangzhou University(Agricultural and Life Science Edition);2008-03
10 XU Xinyue1,HE Biao1,ZHANG Fenghua1,LI Xiaoman1,WANG Fuyan2,CHEN Ze1,FANG Fang1(1.College of Life Sciences,Hunan Nomal University,Changsha 410081,Hunan,China; 2.Xiangya School of Medicine,Central South University,Changsha 410078,Hunan,China);Adjuvant Effect of Lycium Barbarum Polysaccharide to Intranasally Administered Split Pandemic(H1N1) 2009 Influenza Vaccine[J];Acta Laser Biology Sinica;2012-06
China Proceedings of conference Full-text Database 2 Hits
1 WANG Shichang1 LI Yan2 CHEN Jing3 LUO Tingrong1;The immunity efficacy of Sargassum polysaccharides as immunity adjuvant for PRRS virus vaccine[A];[C];2008
2 ;Effect of component drugs from anti-HIV Chinese medicine compound ZL-1 on mice's cell-mediated immunity and its acting mechanism[A];[C];2007
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved