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《Chinese Journal of Virology》 2002-02
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Sequencing and Analysis of the HA1 Gene of Human Influenza Virus(H_3N_2) in China from 1968~2000

WANG Yong 1,2 ,CHEN Shu xia 1,XUE Yin 1,DONG Jie 1,JIN Qi 1,HOU Yun de 1(1.State Key Laboratory for Molecular Virology and Genetic Engineering,Institute of Viral Disease Control and Prevention,China CDC,Beijing 100052,Ch  
HA1 genes of 27 strains of human influenza virus(H 3N 2) in China from 1968~2000 were sequenced,including 7 reference strains:A3/Beijing/1/68,A3/Guangdong/243/72,A3/Beijing/39/75,A3/Guangdong/38/77,A3/Beijing/266/85,A3/Beijing/30/95 and A3/Shanghai/1/98.With bioinformatic tools,analysis of these gene sequences revealed the HA1 gene structure,the mutant regularity,the phylogenesis of HA1 gene sequence and the amino acid sequence.Phylogenetic analysis showed that the human H 3N 2 influenza virus strains in different years were divided into two major lineages,which took subtitution in 1984/1985;and some human strains were closely related to the swine strains in their HA1 sequence.
【Fund】: “973”重点资助课题
【CateGory Index】: R373
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