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《Chinese Journal of Virology》 2009-01
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Effect of the Gardenia Extracts-T9 on Viral Replication and IFN-γ mRNA in Herpes Simplex Virus Type-1 Infected Mice Brains

Shi Yu-jing1,Huang Yang1,Jiang Jing2,Guo Shan-shan1,Su Dan1,Zhao Ye1,Gao Ying-jie1,Cui Xiao-lan1*(1.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;2.Aerospace Center Hospital,Beijing,100049,China)  
RT-PCR was used to detect expression level of VP16 mRNA and IFN-γ mRNA in Herpes simplex virus type-1 infected mice brains at 4th day,7th day,10th day,14th day,21st day post infection and investigate the effects of the Gardenia extracts-T9 on viral replication and host immunity.The results showed that expression of VP16 mRNA in Gardenia extracts-T9 high dose and low dose group were both lower than that in virus control group at same time point.Relative VP16 mRNA expression in low dose group decreased at 21st day and relative VP16 mRNA expression in high dose group decreased continuously.Relative expression of IFN-γ mRNA in high dose and low dose groups were both higher than that in virus control group at all time point except the 4th day.IFN-γ mRNA in low dose group increased from the 4th day till the 14th day,and after the 14th day,the expression decreased slightly.Relative IFN-γ mRNA in high dose group maintained increasing from 4th day till 21st day.Base on these results,we conclude that Gardenia extracts-T9 might exert the inhibition effect of viral replication by upregulating expression of IFN-γ mRNA.
【Fund】: 国家自然科学基金面上项目(30672646);; 国家十一五科技支撑项目(2006BAI08B04-02)
【CateGory Index】: R285.5
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