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《CHINESE JOURNAL OF VIROLOGY》 1997-04
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SUBTYPE AND SEQUENCE ANALYSIS OF THE C2-V3 REGION OF GENES OF MEMBRANE PROTEIN AMONG HIV-1 STRAINS IN WULUMUQI EPIDEMIC AREA OF XINJIANG

Bai Xuhua 1 Guan Yongjun 2 Zhang Yuanzhi 1 Shao Yiming 2 Wang Dongli 1 Su Ling 2 Liu Xiaoliang 2 Zhao Quanbi 2 Du Dawei 3 Josef Kostler 4 Hans Wolf 4  
Seven DNA fragments of HIV-1 env genes were amplified by PCR from uncultured peripheral blood mononuclear cells (PBMCs) obtained from HIV-1 sero-positive drug injecting users (IDUs) in Xinjiang. The C2-V3 region (about 450bp) of them were sequenced. Sequence analysis showed that they are HIV-1 subtypes C, with 1.0% gene divergence among them. The 7 subtype C strains are most close to those found in India and Ruili county of Yunnan, and their nucleotide sequence divergence are both 3.5%. The low level of sequence divergence suggests a recent epidemic of HIV-1 subtype C strain.
【CateGory Index】: R512.91
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