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《CHINESE JOURNAL OF VIROLOGY》 1998-02
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SEQUENCE ANALYSIS OF THE GENES ENCODING VP7 PROTEINS FROM FOUR HUMAN ROTAVIRUS FIELD STRAINS REPRESENTING G1-G4 SEROTYPES

Li Guohua Qian Yuan Xiong Zhaohui Jing Yu (Beijing Municipal Laboratory of Infection and Immunity,Capital Institute of Pediatrics,Beijing 100020)  
Genes coding for the major neutralizing protein(VP7) from four human rotavirus field strains representing serotype 1、2、3 and 4 were cloned and sequenced.These field strains were identified from stool specimens from children with diarrhea in Beijing area.All the VP7 genes from these field strains are 1 062bp long and contain two open reading frames which consist with that reported in the literature.The deduced amino acid identity is high among the VP7 genes of the field strains and the reference strains of same serotypes(92%-94%),whereas among different serotypes,sequences are highly divergent(69%-80%).The divergence of amino acid sequences is mainly within the nine divergent regions.
【CateGory Index】: Q755,R373
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