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《CHINESE JOURNAL OF VIROLOGY》 1998-03
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REGION OF GP120 GENES AMONG HIV-1 STRAINS IN GUANGXI AUTONOMOUS REGION OF THE ZHUANGS

Chen Jie 1 Su Ling 2 Liang Shaoling 1 Liu Wei 1 Liu Xiaoliang 2 Liang Fuxiong 1 Xing Hui 2 Li Rongjian 1 Shao Yiming 2  
HIV-1 env gene were amplified by PCR from uncultured peripheral blood mononuclear cells (PBMCs) from 14 HIV-1 seropositive patients in Guangxi in the mid of 1996.The C2-V3 region(about 450bp) of the amplified DNA fragments were sequenced.Sequence analysis shows that there are two HIV-1 subtypes,B and E with 4.2% and 2.1% gene divergence inside each subtype.The 9 subtype B strains,after compared with sequences of several reference HIV-1 strains,were closely related to those found in Thailand,Myanmar,Yunnan and other provinces in China,and the nucleotide sequence divergence between them ranged from 3.0% to 4.4%;meanwhile,the 5 subtype E strains were most close to the international subtype E,and they are all drug users.The results above suggest that there is a recent epidemic of both B and E subtype HIV-1 strains in Guangxi.
【CateGory Index】: R373,Q319.31
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