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《Acta Scientiarum Naturalium Universitatis Pekinensis》 2007-04
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Research on Multivariate Analysis for Symptom Diagnosis in Traditional Chinese Medicine

WANG Xi 1,SONG Jiannan 2,FANG Xiangzhong 1, 1School of Mathematical Sciences,Peking University,Beijing 100871;2Institute of Basic Theory,China Academy of Chinese Medical Science,Beijing 100700  
Based on the data from the project "Study on the Proteomics about Phlegm and Blood Stasis Symptom in Hyperlipidemia and Atherosclerosis",multivariate analysis are used to help find the most powerful protein groups for TCM symptom diagnosis.Clustering methods on both variables and samples are used for analyzing the 11 proteins,and two possibilities for the variable clustering results are given from the TCM perspective to supervise the sample clustering in different ways.Moreover,hypothesis tests are introduced to support the classification independently.Either the protein group {Haptoglobin(Precursor),α-trypsin inhibitor light chain,ALB protein3,Complement component C4} or the protein group {Fibrinogen gamma chain,α-trypsin inhibitor light chain,undetermined protein(ID1485)} is found to excellently separate not only the symptoms and the control group,but also the phlegm and the blood stasis symptoms.Therefore,suggestions for better TCM symptom diagnosis are given out.
【Fund】: 北京大学“校长基金”;; 教育部科学技术研究(106001)资助项目
【CateGory Index】: R2-03
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhang Zhibin , Wang Yongyan (China Academy of Traditional Chinese Medicine, Beijing 100700);Research on TCM Syndrome Nomenclature and Classification: Review and Hypothesis[J];Journal of Beijing University of Traditional Chinese Medicine;2003-02
【Co-citations】
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1 YU Neng-fu,CHEN Bang-kao(Department of math & physics,Anhui Institute of Architecture & Industry,Hefei,230022);Application of principal component analysis in Analysis of the Students' Grades[J];Journal of Anhui Institute of Architecture & Industry(Natural Science);2007-01
2 DING Chun et al(Anhui Institute of Enviromental Science,Hefei,Anhui 230061);Evaluation of Water Quality Evaluation in the South Feihe River Based on Principal Component Analysis[J];Journal of Anhui Agricultural Sciences;2007-35
3 HU Yu(Guangdong Vocational College of Industry & Commerce,Guangzhou Guangdong 510510,China);PLS Dimensiona Reduction and Quadratic Discriminant Analysis(QDA) to Be Applied on Gene Data Expression Analysis[J];Journal of Anshan Normal University;2007-04
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