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《Acta Zoologica Sinica》 1996-03
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EFFECTS OF CALMODULIN ANTAGONIST (CHLORPROMAZIN HYDROCHLORIDI) ON EARLY PREGNANT OF RAT

YANG REN-SHU, LENG YING, JI LING-DI (Department of Biology, Nanjing Normal University,Nanjing 210024)  
A single injection of a selective antagonist of calmodulin (CaM),into the uterus of 7th day pregnant rat showed a marked effect on fertility. The rate of anti fertility after injection was 98%. Injection of CPZ into rat uterus decreased the CaM content in the tissues of ovary and uterus as well as the serum progesterone level. The distribution of CaM in the ovary was observed by means of immunohistochemical technique. The stained particles of CaM.in the rat ovaries of the experimental group were much less than those in the control group. Moreover, the corpus luteum showed degenerative changes and contained less amount of CaM. The experimental results indicated that CaM plays an important role in the process of rat pregnancy, and its function is closely related to the actions of sexual hormones.
【CateGory Index】: Q954
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1 YANG REN-ZHU LU LING ZOU YU-ZHEN(Dcpt. of Biol. Nanjing Normal University, Nanjing, Jiangsu 210024);CHANGES OF CaM LEVEL IN RAT HYPOTHALAMUS, OVARY AND UTERUS OF RAT IN ACCOMPANY WITH IMMUNOHISTOCHE-MICAL LOCALIZATION OF CaM IN RAT UTERUS DURING ESTROUS CYCLE[J];Acta Zoologica Sinica;1993-01
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