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《Acta Zoologica Sinica》 1997-01
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EFFECTS OF LAMININ AND ITS PEPTIDES ON THE ATTACHMENT AND OUTGROWTH OF MOUSE BLASTOCYSTS

CAO Yu-Jing ZENG Guo-Qing( State Key Laboratory of Reprodutive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China)  
Laminin (LN) is one of the important components of the extracellular matrix. It can interact with the embryo during trophoblast cell invasion. Our experiment showed that LN can remarkably improve the attachment and outgrowth of mouse trophoblasts cultured in the serum free medium in vitro.LN contains some functional peptide sequences such as RGD and YIGSR that have cell-binding activity. We used synthetic peptides RGDS and cYIGSR to test the role of the active sites of LN in the attachment and outgrowth of mouse blastocysts. The results indicate that YIGSR is critical to the improvement of outgrowth of trophoblast cells by LN. On the other hand, we found that RGDS can inhibit both the attachment and outgrowth of blastocysts on the surface of LN-precoated plate, while cYIGSR only inhibits their outgrowth. It suggests that the promotion of attachment and outgrowth of mouse blastocyst by LN is through its specific receptors on the trophoblast cells.
【Fund】: 国家自然科学基金;; 计划生育生殖生物学国家重点实验室资助
【CateGory Index】: Q492
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