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《Acta Zoologica Sinica》 2002-03
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LI Shu Rong ① CHEN Yi Sheng ① WEI Hong ② (① Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China) (② Center for Laboratory Animals, Third Military Medical University, Chongqing 400  
Genetic variation and relationship in ten common strains of mice were studied with RAPD. We attempted to identify DNA polymorphisms that distinguish the ten strains of mice using 80 random primers,21 of the 80 primers generated polymorphic profile among the mice. Each of the strains could easily be distinguished from the others using these polymorphic primers. The results indicated that (1)among the ten strains, the higher genetic distances were detected between DBA/2 and T739,615,C57BL/6J, the genetic distances were 0 162,0 166,and 0 168 respectively; (2) KM had a closer relationship with TA2,BALB/c,BALB/c nu, the genetic distances were 0 060,0 066 and 0 065 respectively; (3)BALB/c and BALB/c nu had the closest relationship. These results coincided with the history of origins and breeds. suitable for mouse genetic monitoring and strains identification.
【Fund】: 国家重点基础研究发展规划项目 (G2 0 0 0 0 16 10 6 );; 国家自然科学基金 (No .396 0 0 0 79、 3990 0 173);; 九五全军医药卫生科研基金 (No .96M 0 83);; 重庆市攻关项目资助~~
【CateGory Index】: Q953
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