EXPRESSION OF TGF-α AND EGF-R mRNA IN THE EARLY EMBRYONIC DEVELOPMENT OF MICE
YAN Yun\|Qin TAN Jing\|He ZHANG Li\|Xia (Northeast Agricultural University, Harbin 150030,China) (Animal Science Institute, Guangdong Province Academy of Agricultural Science, Guangzhou 510001,China)
This study was conducted to examine the activity of TGF α and EGF R mRNA using the RT PCR technique in the early embryonic development of the mouse. Expression of TGF α mRNA was initially observed in the 8 cell stage embryo of the mouse. The level of expression gradually increased in the morula and blastula. Expression of EGF R mRNA was initially observed in the 4 cell stage embryo of the mouse and 8 cell stage embryo;morula and blastula all expressed EGF R mRNA and the levels of expression had not changed. These results confirm that epidermal growth factors play a key role in early embryonic development of the mouse, especially TGF α which can stimulate and regulate embryonic development via the autocrine system.
【CateGory Index】： Q753